Chemistry: natural resins or derivatives; peptides or proteins; – Proteins – i.e. – more than 100 amino acid residues
Patent
1994-11-15
1998-05-26
Fleisher, Mindy
Chemistry: natural resins or derivatives; peptides or proteins;
Proteins, i.e., more than 100 amino acid residues
C07K 1447
Patent
active
057566682
ABSTRACT:
Polynucleotide and polypeptide sequences encoding a novel tumor suppressor, HIC-1, are provided. Also included is a method for detecting a cell proliferative disorder associated, with HIC-1. HIC-1 is a marker which can be used diagnostically, prognostically and therapeutically over the course of such disorders.
REFERENCES:
Baylin, et al., Abnormal Patterns of DNA Methylation in Human Neoplasia: Potential Consequences for Tumor Progression, Cancer Cells, 3(10):383-390, 1991.
Kumagai, et al., Rapid, high-level expression of biologically active .alpha.-trichosanthin in transfected plants by an RNA viral vector, Proc. Natl. Acad. Sci. USA, 90:427-430, 1993.
Pieretti, et al., Hypermethylation at a Chromosome 17 "Hot Spot" Is a Common Event in Ovarian Cancer, Human Pathology, 26(4):398-401, 1995.
Wales, et al., p. 53 activates expression of HIC-1, a new candidate tumor suppressor gene on 17p13.3, Nature Medicine, 1(6):570-577, 1995.
Jones and Buckley, The Role of DNA Methylation in Cancer, Advances in Cancer Research, 54:1-23, 1990.
Baylin Stephen B.
Wales Michele Makos
Fleisher Mindy
McKelvey Terry A.
The Johns Hopkins University School of Medicine
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