Hyperlipemia therapeutic agent

Drug – bio-affecting and body treating compositions – Designated organic active ingredient containing – Having -c- – wherein x is chalcogen – bonded directly to...

Reexamination Certificate

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Details

C514S549000, C514S560000

Reexamination Certificate

active

07022713

ABSTRACT:
The present invention relates to a hyperlipemia therapeutic agent comprising pitavastatins and eicosapentaenoic acid or an ester derivative thereof as effective ingredients.According to the present invention, a type IIb and type IV hyperlipemia therapeutic agent having an excellent effect of lowering the cholesterol and triglyceride in blood is provided.

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McKenney, “New Cholesterol Guidelines, New Treatment Challenges”, Pharmacotherapy, (Jul. 2002), 22(7), 853-63 (Abstract Only, Medline Accession No. 2002380154).
Kiyoshi Mizuguchi, et al., “Ethyl all-cis-5,8,11,14,17-icosapentaenoate modifies the biochemical properties of rat very low-density lipoprotein,” European Journal of Pharmacology, 235 (1993), pp. 221-227.
Kiyoshi Mizuguchi, et al., “The effect of eicosapentaenoic acid ethyl ester (EPA-E) on the metabolism of triglyceride,” J. Jpn. Atheroscier. Soc., 18(5), 1990, pp. 536-537, with English translation.
N. Nakamura, et al., “Joint effects of HMG-CoA reductase inhibitors and eicosapentaenoic acids on serum lipid profile and plasma fatty acid concentrations in patients with hyperlipidemia,” Int J Clin Lab Res (1999) 29, pp. 22-25.
Kiyoshi Mizuguchi, et al., “Mechanism of the lipid-lowering effect of ethyl all-cis-5,8,11,14,17-icosapentaenoate,” European Journal of Pharmacology, 231 (1993), pp. 121-127.
Norio Nakamura, et al., “HMG-CoA Reductase Inhibitors and the Metabolism of Polyunsaturated Fatty Acids-Joint Effects of Eicosapentaenoic Acid and HMG-CoA Reductase Inhibitors”, Progress in Medicine, vol. 19, No. 8, Aug., 1999, pp. 105-111.
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