Hyperhydrated citicoline, process and use

Details Hyperhydrated citicoline, process and use Hyperhydrated citicoline, process and use

1998-12-23

2000-05-02

Wilson, James O.

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Carbohydrate doai

514 50, 514 51, 514951, 424489, A01N 4304

Patent

active

060573015

ABSTRACT:
A hyperhydrated form of citicoline and its formulations, which exhibits desirable characteristics, including crystal formation, moisture resistance, improved storage stability, and formulation versatility, is disclosed. Methods of preparing the citicoline hyperhydrate and its use in the manufacture of stable pharmaceutical dosage forms are also described.

REFERENCES:
patent: 3687932 (1972-08-01), Nakamachi et al.
patent: 4772463 (1988-09-01), Zappia et al.
patent: 4789666 (1988-12-01), Gennari
patent: 4861591 (1989-08-01), Weierstall et al.
patent: 5688510 (1997-11-01), Nakamichi et al.
patent: 5801160 (1998-09-01), Sandage et al.
patent: 5811547 (1998-09-01), Nakamichi et al.
Secades, J.J. and Frontera, G.; CDP-Choline: Pharmacological and Clinical Review. Meth Find Exp Clin Pharmacol 1995; 17 (Suppl B) pp. 1-54.

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