Hyperglycosylated hCG (invasive trophoblast antigen) in...

Chemistry: molecular biology and microbiology – Measuring or testing process involving enzymes or...

Reexamination Certificate

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C435S007100, C435S007210, C435S007230, C530S388100, C530S388240, C530S388800, C530S388850

Reexamination Certificate

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07871762

ABSTRACT:
The invention provides methods for detecting the presence or absence of invasive trophoblast cells. In addition, the invention provides methods for distinguishing quiescent trophoblast diseases from invasive trophoblast diseases and methods for monitoring progression of quiescent trophoblast diseases. The invention provides methods for detecting the presence or absence of germ cell tumors.

REFERENCES:
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Butler SA, Cole LA. Falsely elevated hCG leading to unnecessary therapy (letter). Obstet Gynecol 99:516-517, 2002.
Cole LA, Shahabi S, Oz UA, Bahado-Singh RO, Mahoney MI. Hyperglycosylated hCG (invasive trophoblast antigen) immunoassay: a new basis for gestational down syndrome screening. Clin Chem 1999; 45:2109-2119.
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Elliott MM, Kardana A, Lustbader JW, Cole LA. Carbohydrate and peptide structure of the a- and (3-subunits of human chorionic gonadotropin from normal and aberrant pregnancy and choriocarcinoma. Endocrine 7, 15-32, 1997.
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Sturgeon CM, McAllister EJ, “Analysis of hCG: clinical applications and assay requirements” Ann. Clin. Biochem. 1998; 35: 460-491.

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