Drug – bio-affecting and body treating compositions – Designated organic active ingredient containing – Peptide containing doai
Patent
1991-01-10
1993-08-10
Russel, Jeffrey E.
Drug, bio-affecting and body treating compositions
Designated organic active ingredient containing
Peptide containing doai
514 21, A61K 3728
Patent
active
052349063
ABSTRACT:
Compositions having amylin or an amylin agonist and a glucagon compound, particularly peptide compounds, for the control of glucose production in mammals are provided. The compositions are useful in the treatment of hypoglycemia, including acute hypoglycemic conditions such as those brought on by insulin overdose and the overuse of oral hypoglycemic agents.
REFERENCES:
patent: 4826763 (1989-05-01), Norris et al.
Leighton et al, "Pancreatic Amylin and Calcitonin Gene-Related Peptide Cause Resistance to Insulin . . . ", Nature 335: 632-35 (1988).
Yamaguchi et al, "Calcitonin Gene-Related Peptide and Induction of Hyperglycemia . . . ", Diabetes 39: 168-74 (Feb. 1990).
Molina et al, "Induction of Insulin Resistance In Vivo by Amylin and CGRP", Diabetes 39: 260-65 (Feb. 1990).
Cooper et al., Biochem. Biophys. Acta 1014:247-58 (1989).
Cooper et al., Proc. Nat'l. Acad. Sci., USA 85:7763-66 (1988).
Leighton et al., Diab. Med. 6: Suppl. 2, A14 (1989).
Ciraldi et al., Diabetes 39:149A (1990).
Kreutter et al., Diabetes 39:121A (1990).
Molina et al., Diabetes 39:260-65 (1990).
Koopmans et al., Diabetes 39:101A (1990).
Young et al., Diabetes 39:116A (1990).
V. Marks, "Glucagon in the Diagnosis and Treatment of Hypoglycemia," Chapter 55 of Handbook of Experimental Pharmacology, vol. 66/II, P. J. Lefebvre (Ed.) (Springer-Verlag 1983).
Young et al., Am. J. Physiol. 259:E457-61 (1990).
Leighton et al., Biochem. J. 269--19-23 (1990).
Yamaguchi et al. Diabetes 39:168-74 (1990).
Leighton et al., TIBS 15:295-99 (1990).
Ahren et al., Int'l. Journal of Pancreatology 6:1-15 (1990).
Nishi et al., Journal of Biological Chemistry 265:4173-76.
Clark, Diab. Med. 6:561-67 (1989).
Cooper et al., Diabetes 1988, pp. 493-496, Larkins, Zimmet, and Chisholm (Eds.), (Elsevier Science Publishers B.V. 1989).
Cooper et al., Progress in Growth Factor Research 1:99-105 (1989).
Johnson et al., New England Journal of Medicine 321:513-18 (1989).
Cooper Garth J. S.
Young Andrew
Amylin Pharmaceuticals Inc.
Russel Jeffrey E.
LandOfFree
Hyperglycemic compositions does not yet have a rating. At this time, there are no reviews or comments for this patent.
If you have personal experience with Hyperglycemic compositions, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Hyperglycemic compositions will most certainly appreciate the feedback.
Profile ID: LFUS-PAI-O-1725203