Hylan preparation and method of recovery thereof from animal tis

Details Hylan preparation and method of recovery thereof from animal tis Hylan preparation and method of recovery thereof from animal tis

1990-11-16

1992-03-24

Griffin, Ronald W.

Organic compounds -- part of the class 532-570 series

Organic compounds

Carbohydrates or derivatives

435267, C08B 3708, C08F 800, C12P 1904, C12R 146

Patent

active

050990136

ABSTRACT:
Disclosed is hylan, a chemically modified hyaluronan preparation characterized by the presence of small amounts (0.0002-0.05% by weight) of aldehyde cross-linking groups covalently bonded to the hyaluronan molecular chains. Also disclosed is an improved method of obtaining hylan comprising treating hyaluronan in situ in animal tissues containing same with a treatment mixture including an aldehyde which is reactive towards hyaluronic acid and the proteins contained in the animal tissue. Treatment is effected at temperatures below about 16.degree. C. at very high pH, e.g., 8-14 whereby the overall yield is increased while maintaining the high molecular weight of the hylan.

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