Drug – bio-affecting and body treating compositions – Topical sun or radiation screening – or tanning preparations
Patent
1996-09-23
1998-08-04
Reamer, James H.
Drug, bio-affecting and body treating compositions
Topical sun or radiation screening, or tanning preparations
424 65, 424 701, A61K 742
Patent
active
057889538
DESCRIPTION:
BRIEF SUMMARY
This application is a 371 of PCT/HU95/00007.
BACKGROUND OF THE INVENTION
The present invention relates to hygienic and cosmetic preparations for preventing and treating skin-diseases, including beauty and body-care products, and to a process for obtaining such preparations.
The incidence of cancerous skin-diseases, as is well-known, has suddenly increased in the last years, because the ozone layer surrounding the earth has been growing thin. In the future this tendency seems to be even more significant, since the measures taken nowadays all over the world proved to be insufficient even for maintaining the ozone layer in the present state. This raises the question: how to prevent the development of cancerous skin-diseases.
The increasing number of cancerous skin-diseases due to the thinner ozone layer can be traced back to rising UV doses on the earth surface. Having a strong mutagenic activity, UV radiation can induce genetic mutations in the skin-surface exposed to this radiation. If these genetic mutations take place in the genes playing an important role in the cell cycle regulation, it can significantly increase the possibility of malignant transformations.
There is hardly anyone who has no pigmented birthmarks on the skin-surface. These birthmarks cannot be regarded as malignant tumours, but a malignant transformation can be initiated therein, for example by UV radiation. The solution of this problem seemed to be the preventive ablation of these birthmarks, still at rest, from the skin. This conception, however, proved to be unrealizable, since the operative treatments ought to be extended practically to the whole population of most countries.
Considering that the cancerous skin-diseases belong to the most malignant tumourous diseases, the prevention in this field is of extreme importance. If a perfect ablation of the cancerous parts before spreading the touched cells failed at the first operation, the diseases of this kind turn incurable.
The aim of the present invention is to provide hygienics and cosmetics of therapeutical activity, which make the prevention of cancerous skin-diseases possible by promoting a selection of malignant cells originating from mutations caused for example by UV radiation, just before these cells become numerous enough to create tumours. A further aim of the invention is to provide beauty and body-care products comprising deuterium-depleted water (Dd-water) for retarding ageing processes and treating simpler cutaneous lesions or diseases.
The invention is based on the recognition that unfavourable conditions for the malignant cells can be created and the formation of tumours can be prevented by decreasing locally and temporarily the deuterium content of the water in the upper skin-layer. We have namely discovered that cell-division is triggered by increasing the relative D/H concentration ratio as an element of a submolecular regulation system. The deuterium present in the organism is essential particularly for the tumourous cells having a high proliferation rate.
A further basis of the invention is the recognition that by using water-based cosmetics of decreased (111-135 ppm) deuterium content, the deuterium concentration of the skin is also decreased due to exchange processes. For this reason the preparations with decreased deuterium content are capable of stopping the division of tumourous cells and preventing in this way tumour formation. These preparations therefore can be used for preventing and treating tumourous diseases, for retarding ageing processes in the skin and for treating other skin-diseases, for example psoriasis.
DETAILED DESCRIPTION OF THE INVENTION
In accordance with the above-mentioned facts, the invention relates to hygienic and cosmetic preparations of therapeutical activity, including beauty and body-care products, comprising deuterium in an amount of from 111 to 135 ppm, preferably from 111 to 128 ppm, more preferably from 111 to 118 ppm. The preparations according to the invention are capable of preventing and treating skin-diseases such as
HYD Kutato-Fejleszto Kft.
Jones Dwayne C.
Reamer James H.
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