Hydroxythioether fatty acid derivatives

Details Hydroxythioether fatty acid derivatives Hydroxythioether fatty acid derivatives

1982-08-02

1984-07-24

Trousof, Natalie

Drug, bio-affecting and body treating compositions

Antigen, epitope, or other immunospecific immunoeffector

Recombinant or stably-transformed bacterium encoding one or...

560153, 560154, 562556, 562581, 424313, 424317, 424319, 260399, 260402, C07C14920, C07C149243, A61K 3119, A61K 3122

Patent

active

044617755

ABSTRACT:
Hydroxythioether fatty acid derivatives of formula (I) ##STR1## wherein n is 2-5, m is 8-12, R.sup.1 is OH, O-loweralkyl, NH.sub.2, NH-loweralkyl or NH-carboxyalkyl, R.sup.2 is OH or O-lower-alkyl, X is H or NH.sub.2 or ##STR2## and salts thereof are useful in preventing or alleviating asthma or other allergic diseases.

REFERENCES:
patent: 3366693 (1968-01-01), Randall et al.
Chemical Abstracts, vol. 84, p. 586, Abstract No. 122273w (1976), Gardner et al.
Chemical Abstracts, vol. 87, p. 162, Abstract No. 163021t (1977), Gardner et al.
Chemical Abstracts, vol. 97, p. 58, Abstract No. 33517e (1982), Baker et al.
Tetrahedron Letters, vol. 22, No. 26, pp. 2505-2508 (1981), Baker et al.
Tetrahedron Letters, vol. 22, No. 49, 1981, pp. 4933-4936, Young et al., "The Preparation of Octahydro Leukotrienes C,D, and E Via a Stereoselective Sulfenyllactonization Reaction".

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