Hydroxyquinolone derivatives compounds which have pharmaceutical

Details Hydroxyquinolone derivatives compounds which have pharmaceutical Hydroxyquinolone derivatives compounds which have pharmaceutical

1993-11-18

1994-09-20

Ivy, C. Warren

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Having -c-, wherein x is chalcogen, bonded directly to...

546155, A61K 3147, C07D21548

Patent

active

053489624

ABSTRACT:
This present invention relates to a class of 4-hydroxy-2-(1H)-quinolones which are substituted in the 3-position by an optionally substituted aryl substituent. These compounds are selective non-competitive antagonists of N-methyl-D-aspartate (NMDA) receptors.

REFERENCES:
Helv. Chim. Acta., 1951, vol. 34, pp. 1050-1060 (English Translation).
Z. Naturforsch., 1982, 37b, pp. 1196-1200 (English Translation).
Monatsch. Chem. 1967, vol. 98, pp. 1-8 (English Translation).
Monatsch. Chem. 1969, vol. 100, pp. 951-958 (English Translation).
Monatsch. Chem. 1985, vol. 116, pp. 1005-1015 (English Translation).
Yakugaku zasshi, 1970, vol. 90, pp. 818-828 (English Translation).
British Journal of Pharmacology, Proc. Suppl. Jul. 10-12 (1991), by S. Grimwood, et al.
Proc. Natl. Acad. Sci. USA, vol. 83, pp. 7104-7108, Sep. 1986 Wong et al.
Dickensen and Aydar, Neuroscience Lett. 1991; 121, 263.
Murray, et al Pain, 1991, 44, 179.
Woolf and Thompson, Pain, 1991 44 293.
Trullas and Skolnick, Eur. J. Pharmacol 1990, 185 1.
Kehne, et al Eur. J. Pharmacol., 1991, 193 283.
Werling, et al J. Pharmacol. Exp. Ther, 1990, 255 40.
Marrazzi, et al Life Sciences, 1990 47 PL-41.
Turski, et al Nature (London), Jan. 31, 1991.
Lauritzen, et al, Journ. Of Cerebral Blood Flow and Metabolism 1991, vol. 11, suppl. 2, Abstract XV-4.
Bagetta, et al Br. J. Pharmacol., 1990, 101 776.
Lipton, et al Society for Neuro. Abstr. 1990, 16, 128.11.
van den Pol. et al, science, 1990, 250, 1726.
Urbanski, Endocrinology, 1990, 172 2223.
J. Neurochem., 1985, 45 477.
Neurochem. Int. 1983, 5 479.
Life. Sci., 1981, 28, 1597.
J. Heterocycl. Chem., 1984, 21 737.
Bull. Chem. Soc. Jpn. 1980, 5-1057.
J. Heterocycl. Chem. 1989, 26 281.
J. Heterocycl. Chem., 1975, 12, 351.
J. Heterocycl. chem., 1988, 25, 857.
Journal of Cerebral Blood Flow and metabolism, vol. 11, Suppl. 2, 1991, pp. S222, by M. Lauritzen, et al.

Affiliated with

Also associated with

Rating

Hydroxyquinolone derivatives compounds which have pharmaceutical does not yet have a rating. At this time, there are no reviews or comments for this patent.

If you have personal experience with Hydroxyquinolone derivatives compounds which have pharmaceutical, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Hydroxyquinolone derivatives compounds which have pharmaceutical will most certainly appreciate the feedback.

Rate now

Comments { 0 }

Profile ID: LFUS-PAI-O-2429891