Hydroxyquinoline amines, and method of enhancing memory in mamma

Details Hydroxyquinoline amines, and method of enhancing memory in mamma Hydroxyquinoline amines, and method of enhancing memory in mamma

1988-03-07

1990-07-17

Shah, Mukund J.

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Having -c-, wherein x is chalcogen, bonded directly to...

546159, A61K 3147, C07D21546

Patent

active

049421689

ABSTRACT:
There are disclosed novel compounds of the formula ##STR1## where X is hydrogen, loweralkyl, loweralkoxy, hydroxy, halogen, nitro or trifluoromethyl; R.sub.1 is hydrogen or loweralkyl; R.sub.2 is hydrogen, loweralkyl, arylloweralkyl or --(CH.sub.2).sub.m R.sub.7 wherein m is 1, 2 or 3 and R.sub.7 is cyano or amino; R.sub.3 and R.sub.4 are independently hydrogen or loweralkyl; R.sub.5 and R.sub.6 are independently hydrogen or loweralkyl, or R.sub.5 +R.sub.6 taken together with the carbon atom to which they are attached constitute a cyclobutane, cyclopentane, cyclohexane, cycloheptane, pyrrolidine, piperidine, morpholine or thiomorpholine ring, or R.sub.5 is hydrogen and R.sub.6 is aryl or --CH.sub.2 OR.sub.8 wherein R.sub.8 is hydrogen, loweralkyl or loweralkylcarbonyl, which are useful for enhancing memory.

REFERENCES:
patent: 3957791 (1976-05-01), Simpson
March, "Advanced Organic Chemistry", Second Edition, McGraw-Hill Book Co., p. 358 (1977).
Wright et al., "Synthesis and Hypotens. Prop. of New 4-Aminoquinolines", J. Med. Chem., vol. 14, No. 11 (1971), pp. 1060-1066.

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