Drug – bio-affecting and body treating compositions – Designated organic active ingredient containing – Having -c- – wherein x is chalcogen – bonded directly to...
Reexamination Certificate
2004-12-21
2010-06-29
Wilson, James O (Department: 1624)
Drug, bio-affecting and body treating compositions
Designated organic active ingredient containing
Having -c-, wherein x is chalcogen, bonded directly to...
C544S309000, C544S310000
Reexamination Certificate
active
07745453
ABSTRACT:
Compounds of Formula (1), pharmaceuticals containing the same, especially anti-HIV agents having anti viral activity, especially inhibitory activity against HIV integrase,wherein X represents either one of the following groups:(wherein, C ring is nitrogen-containing aromatic heterocyclic ring in which at least one atom in atoms neighboring the atom bound to the pyrimidine ring is unsubstituted nitrogen atom; R10is hydrogen or lower alkyl; D ring is aryl or heteroaryl) Z1and Z3each is independently a single bond, O, S, S(═O) or SO2; Z2is a single bond, lower alkylene or lower alkenylene; Ar is optionally substituted aryl or optionally substituted heteroaryl; R1is lower alkyl, substituted lower alkyl or the like; R2is a hydrogen atom or optionally substituted lower alkyl; or R1and R2may form, together with an adjacent atom, an optionally substituted heterocyclic ring, a pharmaceutically acceptable salt or a solvate thereof.
REFERENCES:
patent: 2004/0229909 (2004-11-01), Kiyama et al.
patent: 03/016275 (2003-02-01), None
patent: 03/035076 (2003-05-01), None
patent: 03/035077 (2003-05-01), None
Dorwald F. A. Side Reactions in Organic Synthesis, 2005, Wiley: VCH, Weinheim p. IX of Preface.
Vippagunta et. al. Advanced Drug Delivery Reviews 48 (2001) 3-26.
Iwata Minamo
Mikamiyama Hidenori
Taoda Yoshiyuki
Murray Jeffrey H
Shionogi & Co. Ltd.
Wenderoth , Lind & Ponack, L.L.P.
Wilson James O
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