Hydroxyphenylundecane, a process for their production and...

Drug – bio-affecting and body treating compositions – Designated organic active ingredient containing – Ester doai

Reexamination Certificate

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Details

C514S543000, C558S024000, C558S032000, C560S075000

Reexamination Certificate

active

07112608

ABSTRACT:
The present invention relates to novel hydroxyphenylundecane derivatives of the formula (I),a method for the preparation of said compounds by cultivation of the fungusCryphonectria parasitica, DSM 14453, and their use as pharmaceuticals, i.e. for the treatment of Alzheimer's Disease, Parkinson's Disease, Huntington's Diseases, stroke, psychosis and/or depressions.

REFERENCES:
patent: 2327674 (1999-02-01), None
patent: WO 98/04257 (1998-02-01), None
patent: WO 00/04023 (2000-01-01), None
patent: WO 01/23379 (2001-04-01), None
Heinz Stolp, Microbial Ecology: Organisms, Habitats, Activities, Cambridge University Press (1988, pp. 173-181, vol. 180).
Jian Feng et al., Spinophilin Regulates the Formation and Function of Dendritic Spines, Proc. Natl. Acad. Sci. (2000, pp. 9287-9292, vol. 97).
Linda C. Hsieh-Wilson et al., Characterization of the Neuronal Targeting Protein Spinophilin and Its Interactions with Protein Phosphatase-1, Biochemistry (1999, pp. 4365-4373, vol. 38).
Thomas D. Brock et al., Biology of Microorganisms, Prentice Hall (1984, pp.238-247).
Yoshihiro Kumagae et al., Human c-Jun N-Terminal Kinase Expression and Activation in the Nervous System, Molecular Brain Res. (1999, pp. 10-17, vol. 67).
Remington Pharmaceutical Sciences (1985, pp. 1418).

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