Drug – bio-affecting and body treating compositions – Designated organic active ingredient containing – Having -c- – wherein x is chalcogen – bonded directly to...
Patent
1994-05-04
1995-01-31
Brust, Joseph Paul
Drug, bio-affecting and body treating compositions
Designated organic active ingredient containing
Having -c-, wherein x is chalcogen, bonded directly to...
514423, 548517, 548537, 548406, A61K 3140, C07D40506, C07D207327
Patent
active
053859294
ABSTRACT:
2-(4-Fluorophenyl)-.beta.,.delta.-dihydroxy-5-(1-methylethyl)-3-phenyl-4-[( hydroxyphenylamino)carbonyl]-1H-pyrrole-1-heptanoic acid, and their lactone forms, and salts and solyates thereof, inhibit cholesterol biosynthesis, and thus are useful in treating hypercholesterolemia.
REFERENCES:
patent: 4681893 (1987-07-01), Roth
patent: 5216174 (1993-06-01), Butler et al.
patent: 5245047 (1993-09-01), Butler et al.
patent: 5273995 (1993-12-01), Roth
patent: 5280126 (1994-01-01), Butler et al.
patent: 5298627 (1994-03-01), Butler et al.
Pharmaceutical Research (PHReeB) 10(10) S1-S454 (1993) ISSN 0724-8741 "Development and Validation of an Enzyme Inhibition Assay for Quantitation of C1-981 in Human Plasma" Y. Y. Shum et al.
Bjorge Susan M.
Black Ann E.
Roth Bruce D.
Woolf Thomas
Ashbrook Charles W.
Brust Joseph Paul
Warner-Lambert & Company
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