[(Hydroxyphenylamino) carbonyl] pyrroles

Drug – bio-affecting and body treating compositions – Designated organic active ingredient containing – Having -c- – wherein x is chalcogen – bonded directly to...

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514423, 548517, 548537, 548406, A61K 3140, C07D40506, C07D207327

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active

053859294

ABSTRACT:
2-(4-Fluorophenyl)-.beta.,.delta.-dihydroxy-5-(1-methylethyl)-3-phenyl-4-[( hydroxyphenylamino)carbonyl]-1H-pyrrole-1-heptanoic acid, and their lactone forms, and salts and solyates thereof, inhibit cholesterol biosynthesis, and thus are useful in treating hypercholesterolemia.

REFERENCES:
patent: 4681893 (1987-07-01), Roth
patent: 5216174 (1993-06-01), Butler et al.
patent: 5245047 (1993-09-01), Butler et al.
patent: 5273995 (1993-12-01), Roth
patent: 5280126 (1994-01-01), Butler et al.
patent: 5298627 (1994-03-01), Butler et al.
Pharmaceutical Research (PHReeB) 10(10) S1-S454 (1993) ISSN 0724-8741 "Development and Validation of an Enzyme Inhibition Assay for Quantitation of C1-981 in Human Plasma" Y. Y. Shum et al.

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