Hydroxyphenylacetamides having analgesic and anti-irritant activ

Drug – bio-affecting and body treating compositions – Solid synthetic organic polymer as designated organic active... – Polymer from ethylenic monomers only

Patent

Rate now

  [ 0.00 ] – not rated yet Voters 0   Comments 0

Details

424324, 564170, C07C10376, A61K 7155, A61K 31165

Patent

active

044242050

ABSTRACT:
A compound, or pharmaceutically acceptable salt thereof, having the formula: ##STR1## wherein R is a linear or branched C.sub.3 -C.sub.11 alkyl, alkynyl or aralkyl group, a linear or branched C.sub.3 -C.sub.22 alkenyl group, or an unbranched or branched C.sub.6 -C.sub.11 cycloalkyl or cycloalkenyl group; and wherein one of R.sub.1 and R.sub.2 is OH, the other being OH or H. These hydroxyphenylacetamides have analgesic and/or anti-irritant activity when administered either topically or systemically.

REFERENCES:
patent: 3268582 (1966-08-01), Zeile et al.
patent: 4238508 (1980-12-01), Nelson
patent: 4313958 (1982-02-01), LaHann
Sohn, C. H. Boehringer Chemical Abstracts, (1964), #2861f.
Michalska, Zofia et al., Chemical Abstracts, vol. 77, (1972), #19271a.
Kiernan, "A Study of Chemically Induced Acute Inflammation in the Skin of the Rat" Quart. J. Exp. Physiol., vol. 62, (1977), pp. 151-161.
Jansco et al., "Direct Evidence for Neurogenic Inflammation and its Prevention by Denervation and by Pretreatment with Capsaicin," Br. J. Pharm. Chemother., vol. 31, (1967), pp. 138-151.
Arvier et al., "Modification by Capsaicin and Compound 40/80 of Dye Leakage Induced by Irritants in the Rat," Br. J. Pharm., vol. 59, (1977), p. 61-68.
Yaksh et al., "Intrathecal Capsaicin Depletes Substance P in the Rat Spinal Cord and Produces Prolonged Thermal Analgesia," Science, vol. 260, (1979), pp. 481-483.
Virus et al., "Pharmacologic Actions of Capsaicin: Apparent Involvement of Substance P and Serotonin," Life Sciences, vol. 24, (1979), pp. 1273-1281.
Jones et al., "The Relation Between Chemical Constitution and Pungency in Acid Amides," J. Chem. Soc., vol. 27, (1925), p. 2588-2598.
Newman, "Natural and Synthetic Pepper-Flavored Substances," Chem. Prod., (Mar. 1954), pp. 102-106.
Szolesanyi et al., "Sensory Effects of Capsaicin Congeners," Arzneim.-Forsch., vol. 25, (1975), pp. 1877-1881.
Szolesanyi et al., "Sensory Effects of Capsaicin Congeners," Arzneim.-Forsch., vol. 26, (1976), pp. 33-37.
Hegyes et al., "Synthesis of Homovanillic Acid Derivatives of Capsaicin-Like Effect," Acta. Phys. Chem., vol. 20, (1974), pp. 115-120.
T. Szeki, "Contributions Towards Understanding the Relation Between the Chemical Constitution and the Sharp Taste of Acylamines," Arch. Pharm., vol. 268, (1930), pp. 151-157.

LandOfFree

Say what you really think

Search LandOfFree.com for the USA inventors and patents. Rate them and share your experience with other people.

Rating

Hydroxyphenylacetamides having analgesic and anti-irritant activ does not yet have a rating. At this time, there are no reviews or comments for this patent.

If you have personal experience with Hydroxyphenylacetamides having analgesic and anti-irritant activ, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Hydroxyphenylacetamides having analgesic and anti-irritant activ will most certainly appreciate the feedback.

Rate now

     

Profile ID: LFUS-PAI-O-1031648

  Search
All data on this website is collected from public sources. Our data reflects the most accurate information available at the time of publication.