Hydroxynaphthoic acids and derivatives

Organic compounds -- part of the class 532-570 series – Organic compounds – Carboxylic acids and salts thereof

Patent

Rate now

  [ 0.00 ] – not rated yet Voters 0   Comments 0

Details

560 56, 562840, 562867, 564172, C07C 6334, C07C 6976, C07C23300

Patent

active

061244988

ABSTRACT:
In one embodiment, the present invention provides a compound comprising: ##STR1## wherein A=H or OH

REFERENCES:
patent: 4137272 (1979-01-01), Papenfuhs et al.
Bryant, C., et al., "The Incorporation of Radioactivity from [.sup.14 C] Glucose into the Soluble Metabolic Intermediates of Malaria Parasites," (1964), Am J Trop Med Hyg 13, 515-519.
Scheibel, L.W. et al., "Carbohydrate Metabolism in Plasmodium knowlesi," (1970), Comp Biochem Physiol 37, 543-553.
Shakespeare, P.G. et al., "Glucose Catabolism by the Simian Malaria Parasite Plasmodium knowlesi," (1973), Nature 241, 538-540.
Vander Jagt, D.L., et al., "D-Lactate Production in erthrocytes infected with Plasmodium falciparum,"(1990), Mol Biochem Parasitology 42, 277-284.
Sherman, I.W., "Biochemistry of Plasmodium (Malarial Parasites)," (1979), Microbiological Reviews 43, 453-495.
Certa, U., et al., "Aldolase Activity of a Plasmodium falciparum Protein with Protective Properties," (1988), Science 240, 1036-1038.
Kaslow, D.C. et al., "Cloning Metabolic Pathway Genes by Complementation in Escherichia coli," (1990), Journal of Biological Chemistry 265, 12337-12341.
Hicks, K.E., et al., "Glycolytic Pathway of the Human Malaria Parasite Plasmodium falciparum: primary sequence analysis of the gene encoding 3-phosphate kinase and chromosomal studies," (1991), Gene 100, 123-129.
Bzik et al. "Expression of Plasmodium falciparum Lactate Dehydrogenase in Escherichia coli," (1993), Molecular and Biochemical Parasitology 59, 155-166.
Read, M., et al., "Molecular Characterisation of the Enolase Gene from the Human Malaria Parasite Plasmodium falciparum," (1994), Eur. J. Biochem 220, 513-520.
Olafsson, P., et al., "Molecular Analysis of Plasmodium falciparum Hexokinase," (1992), Molecular and Biochemical Parasitology 56, 89-102.
Ranie, J., et al., "Cloning of the Triosephosphate Isomerase Gene of Plasmodium falciparum and Expression in Escherichia coli,"(1993), Mol. Biochem. Parasitology 61, 159-169.
Vander Jagt, D.L., et al., "Partial Purification and Characterization of Lactate Dehydrogenase from Plasmodium falciparum," (1981), Molecular and Biochemical Parasitology 4, 255-264.
Eventhoff, W., et al., "Structural Adaptations of Lactate Dehydrogenase Isozymes," (1977), Proc Natl Acad Sci USA 74, 2677-2681.
Grau, U.M., et al., "Structure of the Active Ternary Complex of Pig Heart Lactate Dehydrogenase with S-lac-NAD at 2.cndot.7 .ANG. Resolution," (1981), J Mol Biol 151, 289-307.
Dunn, C.R., et al., "Design and Synthesis of New Enzymes Based on the Lactate Dehydrogenase Framework," (1991), Phil Trans R Soc Lond B 332, 177-184.
Dunn, C.R., et al., "The Structure of Lactate Dehydrogenase from Plasmodium falciparum Reveals a New Target for Anti-Malarial Design," (1996), Nature Structural Biology 3, 912-915.
Makler, M.T. et al., "Measurement of the Lactate Dehydrogenase Activity of Plasmodium falciparum as an Assessment of Parasitemia," (1993), Am J Trop Med Hyg 48, 205-210.
Makler, M.T., et al., "Parasite Lactate Dehydrogenase as an Assay for Plasmodium falciparum Drug Sensitivity," (1993), Am J Trop Med Hyg 48, 739-741.
Royer, R.E., et al., "Biologically Active Derivatives of Gossypol: Synthesis and Antimalarial Activities of Peri-Acylated Gossylic Nitriles," (1986), Journal of Medicinal Chemistry 29, 1799-1801.
Wilks, H.M., et al., "Design of a Specific Phenyllactate Dehydrogenase by Peptide Loop Exchange on the Bacillus stearothermophilus Lactate Dehydrobenase Framework," (1992), Biochemistry 31, 7802-7806.
Deck, L.M., et al., "Gossypol and Derivatives: A New Class of Aldose Reductase Inhibitors," (1991), Journal of Medicinal Chemistry 34, 3301-3305.
Royer, R.E., et al., "Synthesis and Anti-HIV Activity of 1,1 -Dideoxygossypol and Related Compounds," (1995), Journal of Medicinal Chemistry 38, 2427-2432.
Geren, L.M. et al., "Fluorescence Energy Transfer Studies of the Interaction Between Adrenodoxin and Cytochrome c," (1981), J Biol Chem 256, 10485-10489.
Royer, R.E., et al., "Binding of Gossypol Derivatives to Human Serum Albumin," (1988), Journal of Pharmaceutical Sciences 77, 237-240.
Westheimer, F.H., 1987, in Coenzymes and cofactors, vol. IIA-pyridine nucleotide coenzymes, ed. D. Dolphin, O. Avramovic and R. Poulson, pp. 253-322, John Wiley, New York.
Wilks, H.M., et al., "A Specific, Highly Active Malate Dehydrogenase by Redesign of a Lactate Dehydrogenase Framework," (1988), Science 242, 1541-1544.
Samama, J-P., et al., "An Investigation of the Active Site of lactate Dehydrogenase with NAD.sup.+ Analogues," (1981), Eur. J. Biochem. 120, 563-569.
Sakai, I., et al., "The cDNA and Protein Sequences of Human Lactate Dehydrogenase B," (1987), Biochem. J. 248, 933-936.
Tsujibo, H., et al., "Nucleotide Sequences of the cDNA and an Intronless Pseudogene for Human Lactate Dehydrogenase-A Isozyme," (1985), Eur. J. Biochem. 147, 9-15.
Stangl, D., et al., "Structure and Function of L-Lactate Dehydrogenases from Thermophilic and Mesophilic Bacteria, V," (1987), Biol. Chem. Hoppe-Seyler 368, 1157-1166.
Kunai, K. et al., "Nucleotide Sequence and Characteristics of the Gene for L-Lactate Dehydrogenase of Thermus caldophilus GK24 and the Deduced Amino-Acid Sequence of the Enzyme," (1986), Eur. J. Biochem. 160, 433-440.
Verlinde, C.L.M.J., et al., "Selective Inhibition of Trypanosomal Glyceraldehyde-3-phosphate Dehydrogenase by Protein Structure-Based Design: Toward New Drugs for the Treatment of Sleeping Sickness," (1994), Journal of Medicinal Chemistry 37, 3605-3613.
Gomez, M. A., et al., "Substrate and Cofactor Specificity and Selective Inhibition of Lactate Dehydrogenase from the Malarial Parasite P. falciparum, " (1997), Molecular and Biochemical Parasitology90, 235-246.
Ranie, Jamuna, et al., Cloning of the triosephosphate isomerase gene of Plasmodium falciparum and expression in Escherichia coli from Molecular and Biochemical Parasitology, 61 (1993) 159-170.
Geren, Lois M. and Francis Millett, Fluorescence Energy Transfer Studies of the Interaction between Adrenodoxin and Cytochrome c* from The Journal of Biological Chemistry, vol. 256, No. 20, Issue of Oct. 25, pp. 10485-10489, 1981.
Sherman, Irwin W., Biochemistry of Plasmodium (Malarial Parasites) from Microbiological Reviews, Dec. 1979, p. 453-495.

LandOfFree

Say what you really think

Search LandOfFree.com for the USA inventors and patents. Rate them and share your experience with other people.

Rating

Hydroxynaphthoic acids and derivatives does not yet have a rating. At this time, there are no reviews or comments for this patent.

If you have personal experience with Hydroxynaphthoic acids and derivatives, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Hydroxynaphthoic acids and derivatives will most certainly appreciate the feedback.

Rate now

     

Profile ID: LFUS-PAI-O-2101677

  Search
All data on this website is collected from public sources. Our data reflects the most accurate information available at the time of publication.