Drug – bio-affecting and body treating compositions – Designated organic active ingredient containing – Heterocyclic carbon compounds containing a hetero ring...
Reexamination Certificate
2007-05-29
2007-05-29
Saeed, Kamal A. (Department: 1626)
Drug, bio-affecting and body treating compositions
Designated organic active ingredient containing
Heterocyclic carbon compounds containing a hetero ring...
C514S239500, C544S173000
Reexamination Certificate
active
10509253
ABSTRACT:
A compound represented by the following formula (I)wherein R1and R2are each a lower alkyl group optionally having substituents, which has a calpain inhibitory activity, or a salt thereof is provided.
REFERENCES:
patent: 6057290 (2000-05-01), Fukiage et al.
patent: 6103720 (2000-08-01), Lubisch et al.
patent: 0 641 563 (1995-03-01), None
patent: 6-29229 (1987-01-01), None
FDA mulls drug to slow late-stage Alzheimer's [online], [retrieved on Sep. 23, 2003]. Retrieved from the Internet, URL; http://www.cnn.com/2003/HEALTH/conditions/09/24/alzheimers.drug.ap/index.html>.
A. Arcelli et al., “Unusual Ammonolysis of a Secondary Amide Assisted by Unsubstituted Vicinal Amide Group”, Tetrahedron, vol. 52, No. 11, pp. 4141-4148, 1996.
S. V. Ley et al., “A New Route to Butane-1,2-diacetals and the Development of Alternative Substitution Patterns to Facilitate Differential Protection of the Products”, Synlett., No. 11, pp. 1793-1795, (2001).
K. K. W. Wang et al., “Calpain Inhibition: An Overview of its Therapeutic Potential”, Trends in Pharmacological Sciences, vol.15, pp. 412-419, Nov. 1994.
M. Azuma et al., “Cysteine Protease Inhibitor E64 Reduces the Rate of Formation of Selenite Cataract in the Whole Animal”, Current Eye Research, vol. 10, No. 7, pp. 657-666, 1991.
C. Crawford et al., “The Design of Peptidyldiazomethane Inhibitors to Distinguish Between the Cysteine Proteinases Calpain II, Cathepsin L and Cathepsin B”, Biochem. J., vol. 253, pp. 751-758, 1988.
H. Angliker et al.,“Inactivation of Calpain by Peptidyl Fluoromethyl Ketones”, J. Med. Chem., vol. 35, pp. 216-220, 1992.
Inoue Jun
Nakamura Masayuki
Anderson Rebecca
Saeed Kamal A.
Senju Pharmaceutical Co. Ltd.
Wenderoth , Lind & Ponack, L.L.P.
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