Hydroxymethylene-substituted chromone-3-carboxaldehydes, process

Details Hydroxymethylene-substituted chromone-3-carboxaldehydes, process Hydroxymethylene-substituted chromone-3-carboxaldehydes, process

1974-12-20

1976-02-03

Drezin, Norman A.

Drug, bio-affecting and body treating compositions

Nonspecific immunoeffector, per se ; or nonspecific...

Lipid or oil

A61K 3135

Patent

active

039365638

ABSTRACT:
Novel (hydroxymethylene) chromone derivatives of the general formula I: ##SPC1##
wherein n represents 1 or 2, are prepared by reacting a cycloalkanone II with a boron trifluoride compound and acetic anhydride to obtain novel boron complex intermediates of the formula III: ##SPC2##
wherein n represents 1 or 2, and reacting III with a Vilsmeier reagent prepared from phosphorus oxychloride and dimethylformamide. The final product I and pharmaceutical compositions containing I are useful in the treatment of allergic conditions and in the treatment of hyperacidity.

REFERENCES:
patent: 3786071 (1974-01-01), Cairns
patent: 3816470 (1974-06-01), Tronche

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