Drug – bio-affecting and body treating compositions – Designated organic active ingredient containing – Having -c- – wherein x is chalcogen – bonded directly to...
Reexamination Certificate
2007-03-20
2007-03-20
Davis, Zinna N. (Department: 1625)
Drug, bio-affecting and body treating compositions
Designated organic active ingredient containing
Having -c-, wherein x is chalcogen, bonded directly to...
C546S271400
Reexamination Certificate
active
10546373
ABSTRACT:
Compounds of the formula (I), or a pharmaceutically-acceptable salt, or an in-vivo-hydrolysable ester thereof, (I) R1a is NH(C═W)R5or (a); W is O or S; R2and R3are for example H or F; R1is for example hydrogen, or halogen; R5is selected from hydrogen, (2–6C)alkyl (optionally substituted); R6and R7are independently selected from hydrogen, and (1–4C)alkyl (optionally substituted); wherein R4is either a hydroxymethyl substituent on C-4′ of the isoxazoline ring; or R4is a hydroxymethyl substituent on C-5′ of the isoxazoline ring and the stereochemistry at C-5′ of the isoxazoline ring and at C-5 of the oxazolidinone ring is selected, such that the compound of formula (I) is a single diastereomer; are useful as antibacterial agents; and processes for their manufacture and pharmaceutical compositions containing them are described
REFERENCES:
patent: 2002/0115669 (2002-08-01), Marina et al.
patent: WO 01/94342 (2001-12-01), None
patent: WO 03/022824 (2003-03-01), None
Carcanague Daniel Robert
Gravestock Michael Barry
Hales Neil James
AstraZeneca AB
Davis Zinna N.
LandOfFree
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