Hydroxymethyl-pyridine esters and a process for the preparation

Details Hydroxymethyl-pyridine esters and a process for the preparation Hydroxymethyl-pyridine esters and a process for the preparation

1977-10-05

1980-01-15

Raymond, Richard

Organic compounds -- part of the class 532-570 series

Organic compounds

Heterocyclic carbon compounds containing a hetero ring...

424263, C07D21355

Patent

active

041840402

ABSTRACT:
New hydroxymethyl-pyridine esters of the formula (I) ##STR1## wherein R represents a 9-xanthenyl group or a phenyl group substituted by a halogen atom or a trifluoromethyl group or by an alkyl or alkoxy group, either having 1 to 4 carbon atoms, and pharmaceutically acceptable acid addition salts and quaternary salts thereof are prepared by acylating the corresponding hydroxymethyl pyridines with a carboxylic acid of the formula R--COOH, or with a reactive derivative thereof, and, if desired, converting the obtained product of the formula I into a pharmaceutically acceptable acid addition salt or quaternary salt thereof. The new compounds exert beneficial effects on functional disorders of the heart.

REFERENCES:
patent: 3100775 (1963-08-01), Rorig
patent: 3786059 (1974-01-01), Walther et al.
Harry L. Yale, Journal of Medicinal and Pharmaceutical Chemistry, vol. 1, #2, 1959, pp. 121-133.

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