Hydroxylethylstarch (HES) as plasma expander and process for pre

Details Hydroxylethylstarch (HES) as plasma expander and process for pre Hydroxylethylstarch (HES) as plasma expander and process for pre

1990-06-05

1993-06-08

Nutter, Nathan M.

Organic compounds -- part of the class 532-570 series

Organic compounds

Carbohydrates or derivatives

514 60, C08B 3110, A61K 3172

Patent

active

052181081

ABSTRACT:
A hydroxyethyl starch for use as plasma expander which is obtainable by hydrolytic predegradation of a starch rich in amylopectin, partial hydroxyethylation to a specific substitution degree in the presence of alkali and subsequent hydrolytic degradation to a specific molecular weight, comprises a mean molecular weight of 60,000-600,000 and a substitution degree MS of 0.15-0.5. The ratio of the substitution of C2 to the substitution of C6 of the anhydroglucose units is 8-20 and the substitution degree DS lies in the range from 0.15 to 0.5. A process for the preparation of this hydroxyethyl starch employs 2-chloroethanol as hydroxyethylation agent. The hydroxyethylation is carried out under alkaline conditions at room temperature, the pH value held at a value of about 12 and the temperature held at a value of about 20.degree. C.

REFERENCES:
patent: 4474951 (1984-10-01), Pope
patent: 4629698 (1986-12-01), Nitsch et al.
patent: 4716186 (1987-12-01), Portnoy et al.
patent: 4837314 (1989-06-01), Eastman

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