Hydroxylated metabolites and derivatives of doxazosin as anti-at

Details Hydroxylated metabolites and derivatives of doxazosin as anti-at Hydroxylated metabolites and derivatives of doxazosin as anti-at

1995-05-08

1996-08-06

Jordan, Kimberly

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Having -c-, wherein x is chalcogen, bonded directly to...

514824, A61K 31495, A61K 3150

Patent

active

055434118

ABSTRACT:
This invention relates to the use of certain hydroxylated metabolites and derivatives of doxazosin and their pharmaceutically acceptable acid addition salts for retarding the development of atherosclerosis in a mammal. Such compounds are useful for reducing atherosclerotic plaque involvement and for retarding and reducing both lipid deposition fibrosis in the development of atherosclerotic plaques.

REFERENCES:
patent: 4188390 (1980-02-01), Campbell
patent: 4758569 (1988-07-01), Swindell
Hansch et al., J. Med. Chem., vol. 16, No. 11, pp. 1217-1222 (1973).
Goodman and Gilman's "The Pharmacological Basis of Therapeutics", 8th edition, edited by A. G. Gilman et al., Pergamon Press Inc., New York, 1990, chap. 1, pp. 13-14.
Lipinski, C., Annual Reports in Medicinal Chemistry, 21, chap. 27, pp. 283-291, 1986, Academic Press Inc., Dennis M. Bailey, Ed.
Ryffel et al., Transplantation Proceedings, vol. XX, No. 2, suppl. 2, pp. 575-584 (Apr. 1988).
Schlitt et al., Transplantation Proceedings, vol XIX, No. 5, pp. 4248-4251 (Oct., 1987).

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