Hydroxylated and methoxylated pyrimidyl cyclopentanes as AKT...

Drug – bio-affecting and body treating compositions – Designated organic active ingredient containing – Heterocyclic carbon compounds containing a hetero ring...

Reexamination Certificate

Rate now

  [ 0.00 ] – not rated yet Voters 0   Comments 0

Details

C544S253000

Reexamination Certificate

active

08063050

ABSTRACT:
The present invention provides compounds, including resolved enantiomers, resolved diastereomers, solvates and pharmaceutically acceptable salts thereof, comprising the Formula I:Also provided are methods of using the compounds of this invention as AKT protein kinase inhibitors and for the treatment of hyperproliferative diseases such as cancer.

REFERENCES:
patent: 3885035 (1975-05-01), Simpson
patent: 3956495 (1976-05-01), Lacefield
patent: 3966936 (1976-06-01), Cronin et al.
patent: 4060615 (1977-11-01), Matier et al.
patent: 4352928 (1982-10-01), Hiranuma et al.
patent: 5051412 (1991-09-01), Macor
patent: 5525625 (1996-06-01), Bridges et al.
patent: 5563152 (1996-10-01), Kulagowski et al.
patent: 5610303 (1997-03-01), Kimura et al.
patent: 5750531 (1998-05-01), Lee et al.
patent: 5750545 (1998-05-01), Akahoshi et al.
patent: 5817671 (1998-10-01), Filla et al.
patent: 6310060 (2001-10-01), Barrett et al.
patent: 6423716 (2002-07-01), Matsuno et al.
patent: 6469004 (2002-10-01), Barrett et al.
patent: 6506798 (2003-01-01), Barrett et al.
patent: 6627628 (2003-09-01), Schindler et al.
patent: 6831175 (2004-12-01), Li et al.
patent: 7041687 (2006-05-01), Binch et al.
patent: 7067664 (2006-06-01), Chen
patent: 7115741 (2006-10-01), Levy et al.
patent: 7125880 (2006-10-01), Chen
patent: 7223738 (2007-05-01), Bilodeau et al.
patent: 7223767 (2007-05-01), Clark et al.
patent: 2003/0004193 (2003-01-01), Barrett et al.
patent: 2003/0045521 (2003-03-01), Tecle
patent: 2003/0078428 (2003-04-01), Barrett et al.
patent: 2003/0092748 (2003-05-01), Barrett et al.
patent: 2003/0199511 (2003-10-01), Li et al.
patent: 2003/0216460 (2003-11-01), Wallace et al.
patent: 2003/0232869 (2003-12-01), Wallace et al.
patent: 2004/0053933 (2004-03-01), Pontillo et al.
patent: 2004/0102360 (2004-05-01), Barnett et al.
patent: 2004/0116710 (2004-06-01), Wallace et al.
patent: 2004/0176400 (2004-09-01), Capelli et al.
patent: 2005/0059687 (2005-03-01), Makings et al.
patent: 2005/0130954 (2005-06-01), Mitchell et al.
patent: 2005/0182061 (2005-08-01), Green et al.
patent: 2006/0025074 (2006-02-01), Liang et al.
patent: 2006/0062400 (2006-03-01), Chia-Chun
patent: 2007/0004708 (2007-01-01), Andreotti et al.
patent: 2007/0027156 (2007-02-01), Nakai et al.
patent: 2007/0135466 (2007-06-01), Ledeboer et al.
patent: 2008/0076774 (2008-03-01), Anand et al.
patent: 2008/0188482 (2008-08-01), Rice et al.
patent: 194161 (1986-09-01), None
patent: 95/03286 (1995-02-01), None
patent: 98/43960 (1998-10-01), None
patent: 99/01421 (1999-01-01), None
patent: 99/01426 (1999-01-01), None
patent: 00/40235 (2000-07-01), None
patent: 00/40237 (2000-07-01), None
patent: 00/41505 (2000-07-01), None
patent: 00/41994 (2000-07-01), None
patent: 00/42002 (2000-07-01), None
patent: 00/42003 (2000-07-01), None
patent: 00/42022 (2000-07-01), None
patent: 00/42029 (2000-07-01), None
patent: 00/68201 (2000-11-01), None
patent: 01/05390 (2001-01-01), None
patent: 01/05391 (2001-01-01), None
patent: 01/05392 (2001-01-01), None
patent: 01/05393 (2001-01-01), None
patent: 01/68619 (2001-09-01), None
patent: 02/06213 (2002-01-01), None
patent: 02/18319 (2002-03-01), None
patent: 02/44166 (2002-06-01), None
patent: 02/083139 (2002-10-01), None
patent: 03/022214 (2003-03-01), None
patent: 03/064397 (2003-08-01), None
patent: 03/077855 (2003-09-01), None
patent: 03/077914 (2003-09-01), None
patent: 03/086279 (2003-10-01), None
patent: 03/086394 (2003-10-01), None
patent: 03/086403 (2003-10-01), None
patent: 03/086404 (2003-10-01), None
patent: 03/094918 (2003-11-01), None
patent: 2004/041162 (2004-05-01), None
patent: 2004/096130 (2004-11-01), None
patent: 2005/014558 (2005-02-01), None
patent: 2005/117909 (2005-12-01), None
patent: 2006/046023 (2006-05-01), None
patent: 2006/071819 (2006-07-01), None
patent: 2006/090261 (2006-08-01), None
patent: 2006/136830 (2006-12-01), None
patent: WO 2007042298 (2007-04-01), None
patent: WO 2007077961 (2007-07-01), None
patent: 2007/125320 (2007-11-01), None
patent: 2008/012635 (2008-01-01), None
patent: WO 2008003697 (2008-01-01), None
patent: WO 2008003958 (2008-01-01), None
patent: WO 2008003978 (2008-01-01), None
patent: WO 2008005511 (2008-01-01), None
patent: WO 2008005964 (2008-01-01), None
patent: WO 2008006032 (2008-01-01), None
patent: WO 2008006040 (2008-01-01), None
Vippagunta, S.R., (Adv. Drug. Delivery Rev., 2001, 48, pp. 3-26).
Truong, T. N., “Office Action for U.S. Appl. No. 10/993,173”, United States Patent and Trademark Office, Aug. 6, 2008, 8 pages.
Truong, T. N., “Office Action for U.S. Appl. No. 10/993,173”, United States Patent and Trademark Office, May 26, 2009, 8 pages.
Patent Cooperation Treaty, “International Search Report and Written Opinion of the International Searching Authority”, PCT/US2007/072885, Dec. 3, 2007, 10 pages.
Ohno, S., et al., “Synthesis and Hypoglycemic Activity of 7,8-Dihydro-6H-thiopyrano[3,2-d]pyrimidine Derivatives and Related Compounds”, Chem. Pharm. Bull., 1986, 34(10), 4150-4165.
Zhao, Z., et al., “Discovery of 2,3,5-trisubstituted pyridine derivatives as potent Akt1 and Akt2 dual inhibitors”, Bioorg. Med. Chem. Lett., 2005, 15, 905-909.
Ross, L., et al., “Potential Anticancer Agents. XVIII. Synthesis of Substituted 4,5-Trimethylenepyrimidines”, J. Am. Chem. Soc., 1959, 81, 3108-3113.
Li, Qun “Expert Opinion: Recent Progress in the Discovery of Akt Inhibitors as Anticancer Agents”, Informa Healthcare, 2007, 17(9), pp. 1077-1130.

LandOfFree

Say what you really think

Search LandOfFree.com for the USA inventors and patents. Rate them and share your experience with other people.

Rating

Hydroxylated and methoxylated pyrimidyl cyclopentanes as AKT... does not yet have a rating. At this time, there are no reviews or comments for this patent.

If you have personal experience with Hydroxylated and methoxylated pyrimidyl cyclopentanes as AKT..., we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Hydroxylated and methoxylated pyrimidyl cyclopentanes as AKT... will most certainly appreciate the feedback.

Rate now

     

Profile ID: LFUS-PAI-O-4276126

  Search
All data on this website is collected from public sources. Our data reflects the most accurate information available at the time of publication.