Hydroxylated 24-homo-vitamin D derivatives and methods for prepa

Details Hydroxylated 24-homo-vitamin D derivatives and methods for prepa Hydroxylated 24-homo-vitamin D derivatives and methods for prepa

1986-02-28

1989-08-15

Schenkman, Leonard

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

9,10-seco- cyclopentanohydrophenanthrene ring system doai

2603972, A61K 3159, C07J 900

Patent

active

048575186

ABSTRACT:
This invention is directed to new 24-homo-vitamin D compounds, to methods for preparing the same and novel intermediate compounds.
The compounds are characterized by vitamin D-like activity of the order of 1.alpha.,25-dihydroxyvitamin D.sub.3, the recognized circulating hormonal form of vitamin D, or various of its derivatives and by greater antineoplastic activity than such compounds but without their attendant calcemic activity. The compounds are useful in the treatment of disease states characterized by calcium-phosphorous imbalances and where antineoplastic activity is indicated.

REFERENCES:
patent: 4225596 (1980-09-01), Deluca
patent: 4448721 (1984-05-01), DeLuca et al.

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