Drug – bio-affecting and body treating compositions – Designated organic active ingredient containing – Heterocyclic carbon compounds containing a hetero ring...
Patent
1983-05-26
1985-04-02
Jiles, Henry R.
Drug, bio-affecting and body treating compositions
Designated organic active ingredient containing
Heterocyclic carbon compounds containing a hetero ring...
544131, 544333, 544365, 544405, 546318, 546194, 546257, 546283, 546284, 546280, 546276, 514252, 514269, 514318, 514335, 514340, 514341, 514342, 514356, A61K 31535, A61K 31455, C07D21182, C07D41312
Patent
active
045087199
ABSTRACT:
Compounds of formula I: ##STR1## are described in which R.sup.1 is a linear or branched alkyl radical containing between 1 and 5 carbon atoms, the alkyl radical being unsubstituted or substituted by an alkoxy group; R.sup.2 is an unsubstituted phenyl of phenyl substituted by a nitro group; R.sup.3 is hydrogen or a linear or branched alkyl residue containing between 1 and 4 carbon atoms, the alkyl radical being unsubstituted or substituted by at least one alkoxy or fluorine atom or both alkoxy and fluorine atoms; R.sup.4 is hydrogen or a linear or branched alkyl containing between 1 and 4 carbon atoms, the alkyl radical being unsubstituted or substituted by alkoxy, carbalkoxy, dialkylamino, 1-aryl or 1-heteroarylpiperazinyl, aryl or a monocyclic 5 or 6 membered heterocycle in which at least one of the heteroatoms is N,O,S such as 1-piperidinyl, 4-morpholinyl or R.sub.4 is alkenyl or cyclo(C.sub.3 -C.sub.6)alkyl; and enantiomers, racemates, diastereoisomers and isomers (E) and (Z) and their salts with pharmaceutically acceptable acids.
The novel compounds exhibit calcium-antagonistic activity.
REFERENCES:
patent: 4339584 (1982-07-01), Gruett et al.
Merck Index, Ninth Edition, (1976) p. ONR-80.
Casagrande Cesare
De Marchi Franco
Nicola Massimo
Tricerri Silvia Z.
Bjorkman Dale A.
Jiles Henry R.
Pierrel S.p.A.
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