Hydroxyethylstarch

Details Hydroxyethylstarch Hydroxyethylstarch

2011-01-04

2011-01-04

Olson, Eric S (Department: 1623)

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Carbohydrate doai

C536S111000, C536S123120

Reexamination Certificate

active

07863260

ABSTRACT:
Described are a hydroxyethylstarch, a process for the preparation thereof, a pharmaceutical formulation containing such a hydroxyethylstarch, and the use of the pharmaceutical formulation for the preparation of a volume replacement, a plasma replacement or a plasma volume expander, as well as the use of the pharmaceutical formulation for maintaining normovolemia and/or for improving the macro- and microcirculation and/or for improving the nutritive oxygen supply and/or for stabilizing hemodynamics and/or for improving the volume efficiency and/or for reducing the plasma viscosity and/or for increasing anemia tolerance and/or for hemodilution, especially for therapeutic hemodilution in disturbed blood supply and arterial, especially peripheral arterial, occlusive diseases.

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“STN Database Descriptions” from 2006 Chemical Abstracts Catalog, published 2006 by Chemical Abstracts Service, p. 52.
Felfenig et al., “The effects of hydroxyethyl starch solutions on thromboelastography in preoperative male patients” Acta Anaesthesiol Scand (2003) vol. 47 pp. 70-73.
Deusch, “The Effects of High Molecular Weight Hydroxyethyl Starch Solutions on Platelets” Anesthesia and Analgesia (2004) vol. 99, pp. 665-668.
Jaeger et al., “Effects of colloidal resuscitation fluids on the neutrophil respiratory burst” Transfusion (2001) vol. 41 pp. 1064-1068.
Madjpour et al., “Molecular weight of hydroxyethyl starch: is there an effect on blood coagulation and pharmacokinetics?” British Journal of Anaesthesia (2005) vol. 94 No. 5, pp. 569-576.
De Belder, et al. “The Substitution Patterns of 0-(2-Hydroxyethyl)Starch and 0-(2-Hydroxyethyl)Dextran” Carbohydrate Research, XP002329873 Amsterdam das ganze Dokument, vol. 10, 1969, pp. 391-394.

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