Hydroxyethyl starch and use thereof as an absorbable mechanical

Drug – bio-affecting and body treating compositions – Designated organic active ingredient containing – Carbohydrate doai

Patent

Rate now

  [ 0.00 ] – not rated yet Voters 0   Comments 0

Details

A61K 31135

Patent

active

058078339

ABSTRACT:
Hydroxyethyl starch (HES) and use thereof in methods are provided for reducing or preventing of adhesion formation between tissue surfaces, e.g., organ surfaces, in body cavities following surgical procedures and for drug delivery. HES may be used as an absorbable mechanical barrier alone or in combination with one or more anti-adhesion formation compounds for application to injured areas of tissues, e.g., organs, situated in body cavities such as the peritoneal, pelvic, pleural cavity, central nervous system and interligamentous space. HES may also be used as an intracavity carrier device for delivery of pharmaceutically active agents.

REFERENCES:
patent: 4886787 (1989-12-01), de Belder et al.
patent: 4913903 (1990-04-01), Sudmann et al.
patent: 5080893 (1992-01-01), Goldberg et al.
patent: 5219895 (1993-06-01), Kelman et al.
patent: 5358973 (1994-10-01), Lindblad et al.
patent: 5639468 (1997-06-01), Rogers et al.
diZerega, G.S. & Rodgers, K.E., "Prevention of Postoperative Adhesions," in The Peritoneum, diZerega, G.S. & Rodgers, K.E., eds. Springer-Verlag, New York, pp. 307-369 (1992).
Elkins, T.E., "Can a Pro-Coagulant Substance Prevent Adhesions?" in Treatment of Post-Surgical Adhesions, diZerega, G.S., et al., eds., Wiley-Liss, New York, pp. 103-112 (1990).
Rodgers, K.E., "Nonsteroidal anti-inflammatory drugs (NSAIDs) in the treatment of Postsurgical adhesions," in Treatment of Post-Surgical Adhesion, diZerega, G.S. et al., eds., Wiley-Liss, New York, pp. 119-129 (1990).
Thompson, W.L. (1978) "Hydroxyethyl Starch," in Blood Substitutes and Plasma Expanders, Alan R. Liss, Inc., New York, NY, pp. 283-292.
"Physicians' Desk Reference," 47th Edition, Medical Economics Data Production Co., 1993, pp. 967-968.
diZerega et al (1994) "Use of Instillates to prevent intraperitoneal Adhesions. Crystalloid and Dextra," Infertility and Reprod. Med. Clinics of North America, vol. 5, pp. 463-478.
Cohen et al. (1983) "Use of Intraperitoneal Solutions for Preventing pelvic adhesions in the Rat," J. Reprod. Med., vol. 28, pp. 649-653.
Strauss et al. (1988) "Pentastarch may cause fewer effects on coagulation than hetastarch," Transfusion, vol. 28, pp. 257-260.
London et al. (1989) "A randomized clinical trial of 10% pentastarch (low molecular weight hydroethyl starch) versus 5% albumin for plasma volume expansion after cardiac operations," J. Thorac. Cardiovasc. Surg., vol. 97: 785-797.
Samana, C. et al. (1991) "Absence of side effects of hydroxyethyl starch 200 in a porcine model of experimental arterial thrombosis," Thrombosis Res., vol. 62, pp. 591-598.
Eastlund, D. (1992) "Monocyte chemotaxis and chemotactic cytokine release after exposure to hydroxyethyl starch," Transfusion, vol. 32, pp. 855-860.
Strauss et al. (1986) "Ingestion of hydroxyethyl starch by human leukocytes," Transfusion, vol. 26, pp. 88-90.
Hain, H. et al. (1988) "Prostaglandin E.sub.2, thromboxane B.sub.2, and leukotriene B.sub.4 release from peritoneal macrophages by different osmotic agents in nonuremic guinea pigs," Trans. Am. Soc. Artif. Intern. Organs, vol. XXXIV, pp. 429-432.
Carr, ME. (1986) "Effect of hydroethyl starch on the structure of thrombin-and reptilase-induced fibrin gels," J. Lab. Clin. Med., vol. 108, pp. 556-561.
Kuitunen, A. et al. (1993) "Hydroethyl starch as a prime for cardiopulmonary bypass: Effects of two different solutions on haemostasis," Acta Anaesthesiologica Scandinavica, vol. 37, pp. 652-658.
Collis, R. et al. (1994) "The effect of hydroxyethyl starch and other plasma volume substitutes on endothelial cell activation: an in vitro study," Intensive Care Med., vol. 20, pp. 37-41.
Falk, JL et al. (1988) "Effects of hetastarch and albumin on coagulation in patients with septic shock," J. Clin. Pharmacol., vol. 28, pp. 412-415.
Concettoni et al. (1992) "Thermic and UV instability of hetastarch," Pharmacological Res., vol. 25, pp. 87-88.
Concettoni et al. (1990) "Energy of Activation of hetastarch in a limited range of thermal exposition," Acta Physiologica Hungaria, vol. 75 (Supp.), pp. 59-60.
Nishimura, K. et al. (1984), "Ibuprofen in the Prevention of Experimentally Induced Postoperative Adhesions," Am. J. Med., vol. 77, pp. 102-106.
Querleu et al. (1989), "Adjuvant treatment of tubal surgery. Randomized prospective study of systemically administered corticosteroids and noxythiolinl," J. Gynecol. Obstet. Biol. Reprod. Paris, vol. 18(7), pp. 935-940 (Abstract only).
Mejersijo and Kopp (1987), "Effect of corticosteroid and sodium hyaluronate on induced joint lesions in the guinea-pig knee," Int. J. Oral Maxillofac. Surg., vol. 16(2), pp. 194-201 (Abstract only).
West, R.H. (1992), "The effect of topical corticosteroids on laser-induced peripheral anterior synechiae," Aust. N.Z. J. Opthalmol., vol. 20(4), pp. 305-309 (Abstract only).
Zagorski et al. (1991), "Pathogenesis of secondary glaucoma in epithelial invasion," Klin-Oczna, vol. 93(2-3), pp. 57-58 (Abstract only).
(1991), Clin. Chim. Acta., vol. 203(1), pp. 47-56 (Abstract only).
"Merck Index," 11th Edition, Merck & Co.; editors S. Budavari et al., 1989, Abstract No. 2922, pp. 463-464, Abstract No. 1202, p. 184, Abstract No. 4593, p. 738.
Derwent Publications Ltd. AN 94-0-022820, Dec. 14, 1993.
Strauss et al. (1985), "Effects of Hydroxyethyl Starch on Fibrinogen, Fibrin Clot Formation, and Fibrinolysis," Transfusion, vol. 25, pp. 230-234.
Chemical Abstracts AN 116: 46170, Lehr et al, 1992.

LandOfFree

Say what you really think

Search LandOfFree.com for the USA inventors and patents. Rate them and share your experience with other people.

Rating

Hydroxyethyl starch and use thereof as an absorbable mechanical does not yet have a rating. At this time, there are no reviews or comments for this patent.

If you have personal experience with Hydroxyethyl starch and use thereof as an absorbable mechanical , we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Hydroxyethyl starch and use thereof as an absorbable mechanical will most certainly appreciate the feedback.

Rate now

     

Profile ID: LFUS-PAI-O-87134

  Search
All data on this website is collected from public sources. Our data reflects the most accurate information available at the time of publication.