Organic compounds -- part of the class 532-570 series – Organic compounds – Amino nitrogen containing
Patent
1996-07-10
1998-01-27
O'Sullivan, Peter
Organic compounds -- part of the class 532-570 series
Organic compounds
Amino nitrogen containing
554 61, 554 62, 554 65, 558418, 564141, 564420, 564421, 564422, 564423, C07C23102
Patent
active
057124140
ABSTRACT:
The present invention relates to a process for the preparation of hydroxycarboxylic acid amides of the general formula (1): ##STR1## in which R.sup.1 and R.sup.2 are identical or different and are hydrogen, halogen, cyano, a linear or branched alkyl, alkenyl, alkynyl or alkoxy group having 1 to 12 carbon atoms, an aralkyl group having 7 to 12 carbon atoms, a cycloalkyl group having 6 to 12 carbon atoms or an aryl group having 6 to 12 carbon atoms, R.sup.3 is hydrogen or a linear or branched alkyl group having 1 to 4 carbon atoms, R.sup.4 is hydrogen or a linear or branched alkyl group having 1 to 6 carbon atoms, or R.sup.3 and R.sup.4, together with the carbon atom to which they are attached, form a five- or six-membered cycloalkane ring, and n is an integer from 1 to 12, wherein an aniline of the general formula (2) ##STR2## in which R.sup.1, R.sup.2, R.sup.3 and R.sup.4 are as defined in the formula (1), is reacted with a hydroxycarboxylic acid of the general formula (3) ##STR3## in which n is as defined in the formula (1), in the presence or absence of an inert solvent, at 150.degree. to 250.degree. C., and the constituents which are volatile under the reaction conditions are distilled out of the reaction mixture.
REFERENCES:
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patent: 3538162 (1970-11-01), Dorell
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Synthetic Communications, Bd. 23, Nr. 9, 1993; pp. 2761-2770; Branko S. Jursic et al: "A simple preparation of amides from acids and amines by heating of their mixture".
Dierdorf Andreas
Papenfuhs Theodor
Hoechst Aktiengesellschaft
O'Sullivan Peter
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