Hydroxyazido derivatives and related compounds as renin inhibito

Details Hydroxyazido derivatives and related compounds as renin inhibito Hydroxyazido derivatives and related compounds as renin inhibito

1991-06-07

1993-12-07

Griffin, Ronald W.

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Peptide containing doai

514 18, 530330, 530331, A61K 3702, C07K 506

Patent

active

052683613

ABSTRACT:
Novel compounds useful as renin inhibitors are provided. The compounds are hydroxyazido derivatives having the structural formula ##STR1## wherein the substituents R.sub.1 through R.sub.7 are as defined herein. Analogs of these compounds which are ketozaido derivatives are also provided. Additionally disclosed re methods for using the novel compounds to treat hypertension, and pharmaceutical compositions containing the compounds. Of particular interest are formulations for oral administration.

REFERENCES:
Chemical Abstracts, vol. 111, No. 7, Aug. 14, 1989, Abstract 111:58354v.
Chemical Abstracts, vol. 115, No. 7, Aug. 19, 1991, Abstract 115:72226u

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