Drug – bio-affecting and body treating compositions – Designated organic active ingredient containing – Silicon containing doai
Patent
1997-03-05
1999-11-09
Shaver, Paul F.
Drug, bio-affecting and body treating compositions
Designated organic active ingredient containing
Silicon containing doai
514 24, 514378, 514386, 514389, 514398, 514467, 514561, 514562, 514529, 514546, 514551, 514256, 548240, 548245, 5483491, 540485, 540487, 540528, 549215, 549451, 549452, 556418, 556419, 556420, 556422, 562 26, 562 27, 562433, 562440, 562899, 560147, 560153, 560156, 560168, 564225, 564229, C07F 708, A01N 5500
Patent
active
059815116
ABSTRACT:
The current invention discloses hydroxyamidino derivatives useful as nitric oxide synthase inhibitors.
REFERENCES:
patent: 4713369 (1987-12-01), Stiiber
patent: 5059712 (1991-10-01), Griffith
patent: 5081148 (1992-01-01), Braquet et al.
patent: 5132453 (1992-07-01), Griffith
patent: 5196450 (1993-03-01), Sjoerdsma et al.
patent: 5273875 (1993-12-01), Griffith
patent: 5281627 (1994-01-01), Griffith
patent: 5362744 (1994-11-01), Purchase, Jr. et al.
patent: 5364881 (1994-11-01), Griffith et al.
patent: 5464858 (1995-11-01), Griffith et al.
patent: 5684008 (1997-11-01), Hallinan et al.
Gould et al., "Nucleoside Intermediates in Blasticidin S Biosynthesis Identified by the In Vivo Use of Enzyme Inhibitors", Can. J. Chem., vol. 72, pp. 6-11, 1994.
Tsunematsu et al., ".beta.-Naphthylamides of Guanidinophenyl Amino Acids as Substrates of Aminopeptidases", Chem. Pharm. Bull., vol. 36, No. 3, pp. 1205-1209, 1988.
Funabashi et al., "A New Anti-MRSA Dipeptide, TAN-1057 A", Tetrahedron, vol. 49, No. 1, pp. 13-28, 1993.
Prabhakaran et al., "Studies on Nitrogen Metabolism Using .sup.13 C NMR Spectroscopy. 5..sup.1 Metabolism of L-.alpha.-Arginine in the Biosynthesis of Blasticidin S", Tetrahedron, vol. 27, No. 33, pp. 3815-3818, 1986.
Stuehr et al., "Mammalian Nitric Oxide Synthases", Advances in Enzymology, vol. 65, 1992, (p. 317).
Plapp et al., "Determination of .delta.-Acetimidyllysine in Proteins" Analytical Biochemistry, vol. 62, pp. 291-294, 1974.
Rees et al., "Characterization of Three Inhibitors of Endothelial Nitric Oxide Synthase in vitro and in vivo", Br. J. Pharmacol., vol. 101, pp. 746-752, 1990.
Proudfoot et al., "Conformation-directed Recombination of Enzyme-activated Peptide Fragments: A Simple and Efficient Means to Protein Engineering", J. Bio. Chem., vol. 264, No. 15, pp. 8764-8770, 1989.
Palacios, et al., "Nitric Oxide from L-Arginine Stimulates the Soluble Guanylate Cyclase in Adrenal Glands", Biochemical and Biophysical Research Communications, vol. 165, No. 2, pp. 802-809, 1989.
Knowles et al., "Kinetic Characteristics of Nitric Oxide Synthase from Rat Brain", Biochem. J., vol. 269, pp. 207-210, 1990.
CA 107, 40336y, 1987.
CA 63, 5641d, 1965.
CA 97, 38442m, 1982.
CA 76, 43768t, 1972.
CA 118, 72838g, 1993.
CA 64, 17593h, 1966.
CA 115, 29868t, 1991.
CA 104, 202858, 1986.
Gapud Rolando E.
Hagen Timothy J.
Hallinan Ann E.
Hansen, Jr. Donald W.
Manning Robert E.
G.D. Searle & Co.
Scrivner Alan L.
Shaver Paul F.
LandOfFree
Hydroxyamidino derivatives useful as nitric oxide synthase inhib does not yet have a rating. At this time, there are no reviews or comments for this patent.
If you have personal experience with Hydroxyamidino derivatives useful as nitric oxide synthase inhib, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Hydroxyamidino derivatives useful as nitric oxide synthase inhib will most certainly appreciate the feedback.
Profile ID: LFUS-PAI-O-1456117