Drug – bio-affecting and body treating compositions – Designated organic active ingredient containing – Having -c- – wherein x is chalcogen – bonded directly to...
Patent
1994-06-22
1996-08-27
Gupta, Yogendra N.
Drug, bio-affecting and body treating compositions
Designated organic active ingredient containing
Having -c-, wherein x is chalcogen, bonded directly to...
514274, 544311, 544312, 544313, 544314, A61K 31505, C07D23954
Patent
active
055501320
ABSTRACT:
Novel hydroxyalkylammonium-pyrimidine of the formula ##STR1## and nucleoside derivatives have been found to be useful as inhibitors of inflammatory cytokines. They can be used, inter alia, in the therapy of septic shock, cachexia, rheumatoid arthritis, inflammatory bowel disease, multiple sclerosis and AIDS. The compounds are typically prepared by reaction of an iodo substituted nucleoside with the appropriately substituted hydroxyalkylamine.
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Benson Bradley J.
Chen Xiannong
Cianciolo George J.
Diaz Jose-Luis
Ishaq Khalid S.
Gupta Yogendra N.
Macronex, Inc.
University of North Carolina
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