Hydroxyalkylammonium-pyrimidines and nucleoside derivatives, use

Details Hydroxyalkylammonium-pyrimidines and nucleoside derivatives, use Hydroxyalkylammonium-pyrimidines and nucleoside derivatives, use

1995-06-07

1997-10-21

Gupta, Yogendra N.

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Having -c-, wherein x is chalcogen, bonded directly to...

514 50, 514274, A61K 31505

Patent

active

056796846

ABSTRACT:
Novel hydroxyalkylammonium-pyrimidine of the formula ##STR1## and nucleoside derivatives have been found to be useful as inhibitors of inflammatory cytokines. They can be used, inter alia, in the therapy of septic shock, cachexia, rheumatoid arthritis, inflammatory bowel disease, multiple sclerosis and AIDS. The compounds are typically prepared by reaction of an iodo substituted nucleoside with the appropriately substituted hydroxyalkylamine.

REFERENCES:
patent: 4199574 (1980-04-01), Schaeffer
patent: 5130302 (1992-07-01), Spielvogel et al.
patent: 5306722 (1994-04-01), Kim et al.
patent: 5306732 (1994-04-01), Norris et al.
CA 109:38194, 1988.
Parmely et al. (1993) "Adenosine and a related carbocyclic nucleoside analogue selectively inhibit tumor necrosis factor-alpha production and protect mice against endotoxin challenge" J. Immunol. 151:389-96.
Ruddle et al., 1990, "An antibody to lymphotoxin and tumor necrosis factor prevents transfer of experimental allergic encephalomyelitis" J. Exp. Med. 172:1193-1200.
Sood et al., 1992, "The synthesis and antineoplastic activity of 2'-deoxynucleoside-cyanoboranes in murine and human culture cells" Anticancer Research 12:335-44.
Sood et al., 1990, "Boron-containing nucleic acids. 2. Synthesis of oligonucleoside boranophosphates" J. Am. Chem. Soc. 112:9000-1.
Sood et al., 1989, "Boron-containing nucleic acids. 2. Synthesis of cyanoborane adducts of 2'deoxy-ucleosides" J. Am. Chem. Soc. 111:9234-5.
Spielvogel et al., 1991, "From boron analogues of amino acids to boronated DNA:potential new pharmaceuticals and neutron capture agents" Pure & Appl. Chem. 63:415-8.
Kolb et al. (1985) "Synthesis of No.5:1036-40.
Lee et al. (1994) "Low-molecular-weight TNF biosynthesis inhibitors: strategies and prospectives" Circulatory Shock 44:97-103.

Affiliated with

Also associated with

Rating

Hydroxyalkylammonium-pyrimidines and nucleoside derivatives, use does not yet have a rating. At this time, there are no reviews or comments for this patent.

If you have personal experience with Hydroxyalkylammonium-pyrimidines and nucleoside derivatives, use, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Hydroxyalkylammonium-pyrimidines and nucleoside derivatives, use will most certainly appreciate the feedback.

Rate now

Comments { 0 }

Profile ID: LFUS-PAI-O-1007003