Hydroxyalkyl-piperazino-quinoline nitrates

Details Hydroxyalkyl-piperazino-quinoline nitrates Hydroxyalkyl-piperazino-quinoline nitrates

1974-09-09

1976-05-18

Coughlan, Jr., Paul M.

Chemistry of carbon compounds

Miscellaneous organic carbon compounds

C-metal

260288A, 260288R, 424250, C07D40104

Patent

active

039577910

ABSTRACT:
Disclosed are compounds of the class of quinolines substituted at the 2-, 3- or 4- position by an amino function bearing a hydroxyalkyl nitrate moiety, e.g. 4-(2-hydroxyethylpiperazino)-quinoline nitrate. The compounds have various pharmacological activities in animals and are useful, for example, as hypotensive and anti-anginal agents. Also disclosed are the corresponding hydroxy intermediates which are useful in preparation of the nitrates and also as hypotensive and anti-anginal agents.

REFERENCES:
patent: 3173918 (1965-03-01), Baget et al.
patent: 3856796 (1974-12-01), Simpson
Burger, Medicinal Chemistry, 3rd Ed., Pub. by Wiley-Interscience (1970) pp. 1078 & 1079.
Rhone-Poulenc, Chemical Abstracts, Vol. 63 (1965), Col. 13291.

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