Drug – bio-affecting and body treating compositions – Designated organic active ingredient containing – Heavy metal containing doai
Patent
1997-03-14
1998-12-01
Nazario-Gonzalez, Porfirio
Drug, bio-affecting and body treating compositions
Designated organic active ingredient containing
Heavy metal containing doai
556 13, 556 18, 556 21, 556110, 534 10, 514107, 514108, C07F 902, C07F 112, A61K 3128
Patent
active
058439935
ABSTRACT:
A complex and method for making same for use as a diagnostic or therapeutic pharmaceutical includes a ligand comprising at least one hydroxyalkyl phosphine donor group bound to a gold atom to form a gold-ligand complex that is stable in aqueous solutions containing oxygen, serum and other body fluids.
REFERENCES:
Rush et al., (1987) In vivo and in vitro hepatotoxicity of a novel antienoplastic agent . . . Toxicologist, 7:59 Abstract.
Elder et al. (1981) Nearly regular tetrahedral geometry in a Gold(I) -phosphine complex. X-ray crystal structure of tetrakis . . J. Chem. Soc. Chem. Commun., 900-901.
Forward et al. (1996) Synthesis and structural characterization of tetrahedral four-coordinate Gold(I) complexes . . Inorg. Chem. 35:16-22.
Fricker (1996) Medicinal chemistry and pharmacology of gold compounds. Transition Met. Chem., 21:377-383.
Johnson (1976) in ORTEP -A fortran thermal ellipsoid plot program, Technical Report ORNL-5138, Oak Ridge National Laboratory, Oak Ridge, Tennessee.
Bates and Waters (1984) A tetrahedral complex of Gold(I) . The crystal and molecular structure of . . . Inorg. Chim. Acta, 81:151.
Berglof et al. (1978) Auranofin: an oral chrysotherapeutic agent for the treatment of rheumatoid arthritis. J. Rheumatol., 5:68.
Berners-Price et al. (1984) Stable gold (1) complexes with chelate rings: solution studies of bis (phosphino) . . . J. Chem. Soc. Dalton Trans., 969.
Berning et al., (1996) In vitro and in vivo characterization of 99mTc complex with tris (hydroxymethyl) phosphine (THP) Nucl Med. Biol., 23:617.
Blessing (1995) An empirical correction for absorption anisotropy. Acta Crystallogr., A51:33-38.
Gabe et al. (1989) NRCVAX -an interactive program system for structure analysis. J. Appl. Cryst., 22:384.
Jaw et al., (1989 Crystal structures and solution electronic absorption and MCD spectra for perchlorate and halide salts . . . Inorg. Chem., 28:1028.
Le Page (1988) Computer Programs. J. Appl. Cryst., 21:983-990.
Le Page et al., (1979) Application of a segment dscription of the unique set of reflections to data collection . . . J. Appl. Cryst., 12:464-466.
Mirabelli et al., (1985) Evaluation of the in vivo antitumor activity and in vitro cytotoxic properties of auranofin . . . Cancer Res., 45:32-39.
Pitzer (1979) Relativistic effects on chemical properties. Acc. Chem. Res., 12:271-276.
Pyykko (1988) Relativistic effects in structural chemistry. Chem. Rev., 88:563-594.
Reddy et al. (1996a) Hydroxymethyl bis(phosphines) and their palladium(II) and platinum(II) complexes . . . J. Chem. Soc. Dalton Trans., 1301-1304.
Reddy et al., (1996b) Chemistry in environmentally benign media. Inorg. Chem., 35:1753-1757.
Schubiger et al., (1996) Vehicles, chelators, and radionuclides: choosing the "building blocks" . . . Bioconjugate Chem., 7:165-179.
Shi et al. (1996) Chiral phosphine ligands derived from sugars. 3. Syntheses, structures, and spectroscopic properties . . Inorg. Chem., 35:2742-2746.
Schmidbaur (1995) High-carat gold compounds (Ludwig Mond Lecture) Chem. Soc. Rev., 391-400.
Simon et al., (1981) Screening trail with the coordinated gold compound auranofin using mouse lymphocytic . . . Cancer Res., 41:94-97.
Volkert et al., (1991) Therapeutic radionuclides: production and decay property considerations. J. Nucl. Med., 32:174-185.
Komiya et al., inorganica Chimica Acta, vol. 217, No. 1-2,pp. 201-202, 1994 .
Berning Douglas E.
Katti Kattesh V.
Ketring Alan R.
Volkert Wynn A.
Nazario-Gonzalez Porfirio
The Curators of the University of Missouri
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