Hydroxyalkyl derivatives of aminoglycoside antibiotics

Details Hydroxyalkyl derivatives of aminoglycoside antibiotics Hydroxyalkyl derivatives of aminoglycoside antibiotics

1978-11-07

1980-07-22

Brown, Johnnie R.

Organic compounds -- part of the class 532-570 series

Organic compounds

Carbohydrates or derivatives

435 80, 424180, 536 17R, A61K 3171, C07H 1522

Patent

active

042140749

ABSTRACT:
Certain 2-deoxystreptamine aminoglycoside antibiotics, substituted on the 1-amino group by an alkyl group bearing one or more hydroxy groups, are useful antibacterial agents. The 2-deoxystreptamine aminoglycoside compounds which are substituted in this manner include the kanamycins, the gentamicins, tobramycin, ribostamycin, the neomycins, and 6'-N-alkyl derivatives thereof.

REFERENCES:
patent: 4000261 (1976-12-01), Daniels
patent: 4000262 (1976-12-01), Daniels
patent: 4002742 (1977-01-01), Wright et al.
patent: 4062947 (1977-12-01), Wright et al.
patent: 4085208 (1978-04-01), Mallams et al.

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