Organic compounds -- part of the class 532-570 series – Organic compounds – Heterocyclic carbon compounds containing a hetero ring...
Reexamination Certificate
2006-05-30
2006-05-30
McKane, Joseph K. (Department: 1626)
Organic compounds -- part of the class 532-570 series
Organic compounds
Heterocyclic carbon compounds containing a hetero ring...
Reexamination Certificate
active
07053220
ABSTRACT:
This invention is directed to a class of compounds (Formula I) including hydroxyalkanoyl amino pyrazoles, hydroxyalkanoyl amino thiadiazoles, hydroxyalkanoyl amino acid esters, hydroxyalkanoyl amino acid amides, hydroxyalkanoyl amino alcohols, hydroxyalkanoyl amino ketoes, hydroxyalkanoyl amino hydantoins, hydroxyalkanoyl anilines, and hydroxyalkanoyl derivatives of privileged structures. The invention is also directed to a pharmaceutical formation comprising such compound in a pharmaceutically acceptable salt form or prodrug thereof. The invention is further directed to a method for inhibiting β-amyloid peptide release and/or synthesis, a method for inhibiting γ-secretase activity and a method for treating neurological disorders associated with β-amyloid peptide production. The method comprises administering to a host a pharmaceutical formulation comprising an effective amount of a compound of Formula I. The compounds of Formula I are useful in the prevention and treatment of Alzheimer's disease.
REFERENCES:
Database Cas Online on STN, Chem. Abstr., Accession No. 1972:140733, Khimiya Geterotsiklicheskikh Soedinenii (Luknitskii et al.) (1972), abstract.
International Search Report dated Jun. 19, 2003.
Guameri, et al., Database CAS Online on STN, Chem. Abstr., Accessinon No. 1974:536478, Gazzetta Chimica Italiana, abstract.
Guinn Ashley C.
Pleiss Michael A.
Thorsett Eugene D.
Tung Jay S.
Anderson Rebecca
Elan Pharmaceuticals Inc.
Howrey LLP
Kung Viola T.
McKane Joseph K.
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