Organic compounds -- part of the class 532-570 series – Organic compounds – Amino nitrogen containing
Reexamination Certificate
2008-09-09
2008-09-09
Davis, Brian J (Department: 1621)
Organic compounds -- part of the class 532-570 series
Organic compounds
Amino nitrogen containing
C514S598000
Reexamination Certificate
active
10545556
ABSTRACT:
This invention relates to hydroxy-tetrahydro-naphthalenylurea derivatives and salts thereof which are useful as active ingredients of pharmaceutical preparations. The hydroxy-tetrahydro-naphthalenylurea derivatives of the present invention have an excellent activity as VR1 antagonist and are useful for the prophylaxis and treatment of diseases associated with VR1 activity, in particular for the treatment of urinary incontinence, urge urinary incontinence, overactive bladder, chronic pain, neuropathic pain, postoperative pain, rheumatoid arthritic pain, neuralgia, neuropathies, algesia, nerve injury, ischaemia, neurodegeneration, stroke, inflammatory disorders, asthma and COPD.
REFERENCES:
patent: WO 00/29577 (2000-05-01), None
patent: WO 00/50387 (2000-08-01), None
Fujishima Hiroshi
Masuda Tsutomu
Mogi Muneto
Moriwaki Toshiya
Tajimi Masaomi
Bayer Healthcare AG
Davis Brian J
Edwards Angell Palmer & & Dodge LLP
Loren Ralph A.
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