Hydroxy protecting group removal in penems

Details Hydroxy protecting group removal in penems Hydroxy protecting group removal in penems

1995-03-06

1995-10-10

Rizzo, Nicholas

Organic compounds -- part of the class 532-570 series

Organic compounds

Heterocyclic carbon compounds containing a hetero ring...

540312, C07D49900

Patent

active

054571936

ABSTRACT:
The present invention relates the removal of t-butyldimethylsilyl protecting groups in the preparation of penems which are useful antibiotics. The invention provides a process for preparing a compound of the formula I: ##STR1## wherein R is a free or protected hydroxy or amino group or an alkoxy, acyloxy or an optionally substituted carbamoyloxy group, and R.sub.1 is selected from:

REFERENCES:
Tetrahedron Letters, No. 41, 1979, pp. 3981-3982, R. F. Newton, et al., "Excellent Reagent For The Removal Of The T-Butyldimethylsilyl Protecting Group".
Chemical Abstracts, vol. 112, No. 21, 1990, Abstract No. 197969h, JP-A-1 254 656, Oct. 11, 1989.

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