Drug – bio-affecting and body treating compositions – Designated organic active ingredient containing – Nitrogen containing other than solely as a nitrogen in an...
Patent
1996-02-06
1999-10-05
Dees, Jose' G.
Drug, bio-affecting and body treating compositions
Designated organic active ingredient containing
Nitrogen containing other than solely as a nitrogen in an...
514669, 514667, 514867, 564503, 564506, A61K 3113, C07C21500
Patent
active
059625333
ABSTRACT:
Disclosed are polyamines having the formula: ##STR1## or salts or stereoisomers thereof wherein R.sub.1 -R.sub.4 and ALK.sub.1 -ALK.sub.3 are as defined in the specification. Pharmaceutical compositions and therapeutic methods of treatment utilizing the compounds are also disclosed.
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patent: 5541230 (1996-07-01), Basu et al.
Basu et al., "Effects of variation in the structure of spermine on the association with DNA and the induction of DNA conformational changes". Biochem. J. vol. 269, 329-334, 1990.
Edwards et al., "Synthesis and DNA-binding properties of polyamine analogues". J. Med. Chem. vol. 34, 2414-2420, 1991.
Stein, "Internal Medicine", 4th edition, pp. 699-715, 1995.
Badio Barbara
Clarke Dennis P.
Dees Jos,e G.
University of Florida Research Foundation Inc.
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