Organic compounds -- part of the class 532-570 series – Organic compounds – Carboxylic acid esters
Patent
1997-03-11
2000-03-28
Reamer, James H.
Organic compounds -- part of the class 532-570 series
Organic compounds
Carboxylic acid esters
560185, 560186, 560187, 549500, 514467, 514461, 514533, 514547, C07C 69612
Patent
active
060433892
ABSTRACT:
This invention relates to compositions for and methods of treating, preventing or ameliorating cancer and other proliferative diseases as well as methods of inducing wound healing, treating cutaneous ulcers, treating gastrointestinal disorders, treating blood disorders such as anemias, immunomodulation, enhancing recombinant gene expression, treating insulin-dedendent patients, treating cystic fibrosis patients, inhibiting telomerase activity, treating virus-associated tumors, especially EBV-associated tumors, augmenting expression of tumor suppressor genes, inducing tolerance to antigens, or treating, preventing or ameliorating protozoan infection or inhibiting histone deacetylase in cells. The compositions of the invention are to and the methods of the invention use hydroxy and ether-containing oxyalkylene esters.
REFERENCES:
patent: 2940855 (1960-06-01), Beavers et al.
patent: 3219630 (1965-11-01), Sidi
patent: 3293220 (1966-12-01), Minami et al.
patent: 3336262 (1967-08-01), Sidi
patent: 3700722 (1972-10-01), McTeer
patent: 3720706 (1973-03-01), Lapporte et al.
patent: 3812176 (1974-05-01), Lapporte et al.
patent: 3931412 (1976-01-01), Kensler, Jr. et al.
patent: 4012526 (1977-03-01), Kensler, Jr. et al.
patent: 4105681 (1978-08-01), Bollag et al.
patent: 4123552 (1978-10-01), Kensler, Jr. et al.
patent: 4198416 (1980-04-01), Koeda et al.
patent: 4215215 (1980-07-01), Bollag et al.
patent: 4479963 (1984-10-01), Gruenfeld
patent: 4541944 (1985-09-01), Sanderson
patent: 4545784 (1985-10-01), Sanderson
patent: 4613505 (1986-09-01), Mizushima et al.
patent: 4699925 (1987-10-01), Uchida et al.
patent: 4760057 (1988-07-01), Alexander
patent: 4885311 (1989-12-01), Parish et al.
patent: 4900478 (1990-02-01), Gross
patent: 4916230 (1990-04-01), Alexander
patent: 4927966 (1990-05-01), Kalmen
patent: 5025029 (1991-06-01), Perrine
patent: 5030654 (1991-07-01), Barnish et al.
patent: 5158773 (1992-10-01), Gross
patent: 5185436 (1993-02-01), Villa et al.
patent: 5196567 (1993-03-01), Uchida et al.
patent: 5200553 (1993-04-01), Nudelman et al.
patent: 5216004 (1993-06-01), Perrine
patent: 5412137 (1995-05-01), Prashad et al.
patent: 5569675 (1996-10-01), Rephaeli et al.
patent: 5710176 (1998-01-01), Rephaeli et al.
Holmes et al, Chem. Abstracts, vol. 118, #191,195e, 1993.
Klaveness et al, Chem. Abstracts, vol. 117, #198,512u, 1992.
Thiele et al, Chem. Abstracts, vol. 83, #178,549n, 1975.
Brant and Conklin, "Acrolein Diacylates", Chem. Abstracts, vol. 40, p.3127, 1946.
Carstea, et al., "Analogues of Butyric Acid that Increase the Expression of Transfected DNAs", Biochem. Biophys. Res. Com., vol. 192, No. 2, pp. 649-656, 1993.
Cheng, et al., "Functional Activation of the Cystic Fibrosis Trafficking Mutant deltaF508-CFTR by Overexpression", American Journal of Physiology, vol. 268, No. 4, pp. L615-L624, 1995.
Holmes, et al., "Preparation of Acylals and Analogs for Preparation of Biolabile Crosslinked Ultrasound Imaging Agents", Chem Abstracts, vol. 118, Abstract#191,195e,1993.
Ingram and Thomas, "The Electron Impact Induced Fragmentation of Geminal Dialkanoates", Organic Mass Spectrometry, vol. 12, No. 4, pp. 216-221, 1977.
Klaveness, et al, "Polymers Containing Diester Units for Prosthetics and Dosage Forms", Chem Abstracts, vol. 117, Abstract#198,512u, 1992.
Liu et al., "Cinnamic Acid: A Natural Product with Potential Use in Cancer Intervention", Int. J. Cancer, vol. 62 pp. 345-350, 1995.
Man, et al., "Boron Fluoride Catalyzed Addition of Aliphatic Anhydrides to Aldehydes", J. Am. Chem. Soc., pp. 847-848, 1950.
Miller, et al., "Clinical Pharmacology of Sodium Butyrate in Patients with Acute Leukemia", Eur. J. Cancer Clin Oncol. vol. 23, No. 9, pp. 1283-1287, 1987.
Mosher and Kehr, "The Oxidation of Aliphatic Esters with Lead Tetraacetate", J. Am. Chem. Soc., vol. 82, pp. 5342-5345, 1960.
Nielsen and Bundgaard, "Evaluation of Glycolamide Esters and Various Other Esters of Aspirin as True Aspirin Prodrugs", J. Medicinal Chem., vol. 32, pp. 727-734, 1989.
Novogrodsky, et al., "Effect of Polar Organic Compounds on Leukemic Cells", Cancer, vol. 51, No. 1, pp. 9-14, 1983.
Nudelman, et al., "Novel Anticancer Prodrugs of Butyric Acid", J. Med. Chem., vol. 35, pp. 687-694, 1992.
Oh, et al., "Convenient Synthesis of Geminal Biscarboxylates: Searching for an Efficient Route to HR 916B", Korean J. Med. Chem., vol. 6, No. 2, pp. 259-262, 1996.
Rephaeli, et al., "Butyrate-Induced Differentiation in Leukemic Myeloid Cells: in vitro and in vivo Studies", International Journal of Oncology, vol. 4, No. 6, pp. 1387-1391, 1994.
Sher, et al., "Extended Therapy with Intravenous Arginine Butyrate in Patients with Beta--Hemoglobinopathies", New England Journal of Medicine, vol. 332, No. 24, pp. 1606-1610, 1995.
Smith, et al., "Incorporation of Tributyrin Enhances the Expression of a Reporter Gene in Primary and Immortalized Cell Lines", Biotechniques, vol. 18, No. 5, pp. 852-855, 1995.
Stamatoyannopoulos, et al., "Therapeutic Approaches to Hemoglobin Switching in Treatment of Hemoglobinopathies", Ann. Rev. Med., vol. 43, pp. 497-522, 1992.
Tang, et al., "Butyrate-Inducible and Tumor-Restricted Gene Expression by Adenovirus Vectors", Cancer Gene Therapy, vol. 1, No. 1, pp. 15-20, 1994.
Thiele, et al., "Cholesterol Lowering Agents", Chem Abstracts, vol. 83, #178,549n, 1975.
Tomiska and Spousta, "Low-Molecular Polyoxymethylene Diacetates from Trioxane", Angew. Chem. Internat. Edit., vol. 1, No. 4, p. 211, 1962.
Nudelman Abraham
Rephaeli Ada
Bar-Ilan University
Beacon Laboratories, Inc.
Mor Research Applications Ltd.
Reamer James H.
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