Drug – bio-affecting and body treating compositions – Designated organic active ingredient containing – Having -c- – wherein x is chalcogen – bonded directly to...
Patent
1985-07-24
1987-12-08
Ford, John M.
Drug, bio-affecting and body treating compositions
Designated organic active ingredient containing
Having -c-, wherein x is chalcogen, bonded directly to...
514275, 544298, 544330, 544331, 544332, A61K 31505, C07D23947, C07D40104
Patent
active
047118881
ABSTRACT:
2-Amino-4-substituted-5-(hydroxy or alkoxy)pyrimidines, which may be 6-substituted, and derivatives thereof are inhibitors of leukotriene synthesis and are therefore useful for the treatment of pulmonary, inflammatory, allergic and cardiovascular diseases. The compounds are also cytoprotective and therefore useful in the treatment of peptic ulcers.
REFERENCES:
patent: 4554276 (1985-11-01), LaMattina
LaMattina et al., Tetrahedron Letters, vol. 25, pp. 2957-2960 (1984).
LaMattina, Chemical Abstracts, vol. 103, entry 14200u (1985).
LaMattina, Chemical Abstracts, vol. 101, entry 211082v (1984).
Wang et al, Chemical Abstracts, vol. 101, entry 55042z (1984).
Hirata et al, Chemical Abstracts, vol. 67, entry 90759q (1967).
LaMattina John L.
Walker Frederick J.
Akers Lawrence C.
Ford John M.
Holtrust Gezina
Pfizer Inc.
Richardson Peter C.
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