Hydroxy alkyl amines

Drug – bio-affecting and body treating compositions – Designated organic active ingredient containing – Having -c- – wherein x is chalcogen – bonded directly to...

Reexamination Certificate

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C514S351000, C514S423000, C514S445000, C514S461000, C514S625000, C546S242000, C546S300000, C548S530000, C549S062000, C549S475000, C564S193000

Reexamination Certificate

active

07144897

ABSTRACT:
Disclosed are compounds of formula X,which are useful in treating Alzheimer's disease and other similar diseases. Pharmaceutical compositions comprising compounds of formula X and methods of preparing the compounds of formula X are also disclosed.

REFERENCES:
patent: 4522811 (1985-06-01), Eppstein et al.
patent: 5387742 (1995-02-01), Cordell
patent: 5441870 (1995-08-01), Seubert et al.
patent: 5593846 (1997-01-01), Schenk et al.
patent: 5604102 (1997-02-01), McConlogue et al.
patent: 5612486 (1997-03-01), McConlogue et al.
patent: 5720936 (1998-02-01), Wadsworth et al.
patent: 5721130 (1998-02-01), Seubert et al.
patent: 5744346 (1998-04-01), Chrysler et al.
patent: 5766846 (1998-06-01), Schlossmacher et al.
patent: 5811633 (1998-09-01), Wadsworth et al.
patent: 5850003 (1998-12-01), McLonlogue et al.
patent: 5877015 (1999-03-01), Hardy et al.
patent: 5877399 (1999-03-01), Hsiao et al.
patent: 5912410 (1999-06-01), Cordell
patent: 5942400 (1999-08-01), Anderson et al.
patent: 6191166 (2001-02-01), Audia et al.
patent: WO 98/22597 (1998-05-01), None
patent: WO 98/33795 (1998-08-01), None
patent: WO 99/64001 (1999-08-01), None
patent: WO 00/03819 (2000-01-01), None
patent: WO 00/17369 (2000-03-01), None
patent: WO 00/47618 (2000-08-01), None
patent: WO 00/56335 (2000-09-01), None
patent: WO 01/10387 (2001-02-01), None
patent: WO 01/23533 (2001-04-01), None
patent: WO 01 53255 (2001-07-01), None
patent: WO 01 66564 (2001-09-01), None
patent: WO 01 70672 (2001-09-01), None
patent: WO 02/02506 (2002-01-01), None
Branalt J. et al., (1997)Tetrahedron Letters38(19):3483-3486.
International Search Report for International Application PCT/US 02/17698.
Hyafil, et al., “In Vitro and In Vivo Reversal of Multidrug Resistance by GF120918, an Acridonecarboxamide Derivate” Cancer Research, (1993) 53: pp. 4595-4602.
Dantzig et al., “Reversal of P-Glycoprotein—mediated Multidrug Resistance by a Potent Cyclopropyldibenzosuberane Modulator, LY335979” Cancer Research, (1996) 56: pp. 4171-4179.
Hussaine et al., “Identification of a Novel Aspartic Protease (Asp2) as β-Secretase” Mol Cell. Neurosci. (1999) 14: pp. 419-427.
Gould, “Salt selection for basic drugs” Int. J. Pharm. (1986) 33: pp. 201-217.
Getman, et al., “Discovery of a Novel Class of Potent HIV-1 Protease Inhibitors Containing the (R)—(Hydroxyethyl) urea Isostere” J. Med. Chem., (1993) 36: pp. 288-291.
Vasquez, et al., “Inhibitors of HIV-1 Protease Containing the Novel and Potent (R)—(Hydroxyethyl) sulfonamide Isostere” J. Med. Chem., (1995) 38: pp. 581-584.
Berge et al., “Pharmaceutical Salts” J. Pharm. Sci. (1977) 66(1): pp. 1-19.
Kang et al., “The precursor of Alzheimer's disease amyloid A-4 protein resembles a cell-surface receptor” Nature (1987) 325: pp. 733-736.
Kitaguchi et al., “Novel precursor of Alzheimer's disease amyloid protein shows protease inhibitory activity” Nature (1981) 331: pp. 530-532.
Arrowsmith et al, “Amino-Alcohol Dipeptide Analogues: a Simple Synthesis of a Versatile Isostere For the Development of Proteinase Inhibitors” Tetrahedron Letters, (1987) 28: pp. 5569-5572.
Shibata, et al., “An Expeditious Synthesis of (2R,3S)-3-tert-Butoxycarbonylamino-1isobutylamino-4phenyl-2-butanol, a Key Building Block of HIV Protease Inhibitors” Tetrahedron Letters, (1997) 38: pp. 619-620.
Vassar et al., “β-Secretase Cleavage of Alzheimer's Amyloid Precursor Protein by the Transmembrane Aspartic Protease BACE” Science (1999) 286: pp. 735-741.
Yan et al., Membrane-anchored asparty1 protease with Alzheimer's disease β-secretase activity Nature (1999) 402: pp. 553-537.

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