Drug – bio-affecting and body treating compositions – Designated organic active ingredient containing – Radical -xh acid – or anhydride – acid halide or salt thereof...
Patent
1995-05-30
1997-08-12
Kumar, Shailendra
Drug, bio-affecting and body treating compositions
Designated organic active ingredient containing
Radical -xh acid, or anhydride, acid halide or salt thereof...
514558, 514561, 514563, 514616, 514844, 514845, 514880, 514881, 554 35, 554 36, 554106, 564152, 564155, 564159, 564201, A61K 31195, C07C22924
Patent
active
056566689
DESCRIPTION:
BRIEF SUMMARY
This is a 371 of PCT/GB93/02061; filed Oct. 4, 1993.
FIELD OF THE INVENTION
This invention concerns cosmetic compositions, particularly those including so-called "pseudoceramides", and relates to a novel class of pseudoceramides and their use in the treatment of skin, hair and nails.
BACKGROUND OF THE INVENTION
Ceramides are a group of naturally occurring compounds having the formula shown in FIG. 1, where m=10-16 and n=12-24. Ceramides and ceramide derivatives are believed to play an important role in the water permeability properties of the skin, functioning to give increased strength to the skin structure to decrease water loss and so improve the condition of the skin, and it is known to use ceramides and ceramide derivatives as components of skin care compositions.
Certain non-naturally occurring variants of ceramides, known as pseudoceramides, have been synthesised or proposed. Generally these are designed to have certain properties similar to those of ceramides and to mimic the behaviour of ceramides in relation to the skin so as to be usable in skin care compositions as cheaper substitutes in place of naturally occurring skin ceramides.
Known pseudoceramides include those described in EP 0420722 A of L'Oreal and EP 0482860 A of Unilever.
The present invention is based on a novel class of pseudoceramides.
SUMMARY OF THE INVENTION
In one aspect the present invention provides compounds of the formula shown in FIG. 2, in which: carbons;
R1 may be an aliphatic hydrocarbon, and preferably has 10-24 C atoms, more preferably 16-18 C atoms.
Compounds in accordance with the invention have certain properties similar to those of naturally occurring skin ceramides, and can thus be considered to constitute a novel class of pseudoceramides.
The compounds of the invention thus find application in the treatment of skin, hair and nails.
In a further aspect the invention thus provides a composition, particularly a cosmetic composition, suitable for topical application to skin, hair or nails, comprising a compound in accordance with the invention.
The invention also covers use of a compound in accordance with the invention as an agent for skin water barrier repair, for improving nails and/or for improving hair.
The composition may include one or more compounds in accordance with the invention, conveniently in an amount in the range 0.00001 to 50% by weight, preferably 0.001 to 20% by weight, more preferably 0.1 to 10% by weight, eg 0.8 to 5.0% by weight.
The composition preferably includes a suitable carrier vehicle for the compound. This will generally be a cosmetically acceptable vehicle which acts as a diluent, dispersant or carrier to enable the compound to be dispersed onto the skin, hair or nails and distributed thereon.
Suitable carrier vehicles include water, liquid or solid emollients, solvents, humectants and powders. Examples of these types of vehicles, which can be used singly or as mixtures, are given in EP 0482860 A.
The carrier vehicle will usually form from 10 to 99.9% by weight, preferably from 50 to 90% by weight, of the composition, and can, in the absence of other cosmetic adjuncts, form the balance of the composition.
Optional skin benefit materials and cosmetic adjuncts may also be included.
Compounds in accordance with the invention are found to have excellent emulsifying, gelling and thickening properties and are well suited to use in formulations in the form of viscous emulsions or gels.
A particularly convenient form of the composition according to the invention is an emulsion, in which case an oil or oily material will normally be present, together with an emulsifier (if required) to provide either a water-in-oil emulsion or an oil-in-water emulsion, depending largely on the average hydrophilic-lyophilic balance (HLB) of the emulsifier employed.
The composition according to the invention can optionally comprise one or more oils or other materials having the properties of an oil.
Examples of suitable oils include mineral oil and vegetable oils, and oil materials, such as those already
REFERENCES:
patent: 4978786 (1990-12-01), Messina et al.
Linfield, et al, JAOCS, vol. 65, No. 5 (May 1988) pp. 820-825.
Michich, T.J. et al: "Wetting properties of nonionics from branched fatty diamides", JAOCS, J.A., Oil Chem Soc., 65(5), 820-5 1988.
Janousek Angela
Motion Keith Robert
Watkins Stephen David
Kumar Shailendra
Quest International B.V.
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