Hydroxy acids

Details Hydroxy acids Hydroxy acids

1977-10-25

1979-03-20

Trousof, Natalie

Drug, bio-affecting and body treating compositions

Nonspecific immunoeffector, per se ; or nonspecific...

Synthetic or structurally-modified peptidoglycan or...

2603436, C07D30732, A61K 31365

Patent

active

041454375

ABSTRACT:
The invention concerns novel racemic and optically active mono- and di-hydroxy alkanoic acids bearing phenyl and/or alkyl substituents, processes for their preparation, and pharmaceutical compositions for therapeutic use in the treatment of duodenal or gastric ulcers. Representative compounds of the invention are 2-(5.beta.-n-butyl-4.beta.-hydroxy-2-oxo-tetrahydrofuran-3.beta.-yl)-2.alp ha.-methyl-acetic acid and 3.alpha.-methyl-5.beta.-(1.beta.-hydroxy-n-pentyl)-2-oxo-tetrahydrofuran-4 .beta.-ylcarboxylic acid.

REFERENCES:
beereboom, et al., Jour. Org. Chem. 1965, 30, 1231-1233.
H. Stobbe, Annalen. 1899, 308, 144-155, R Fittig Annalen, 1899, 305, 1-18, R. Fittig Annalen, 1899, 304, 311-325.
McCorkindale et al., Tetrahedron letters, No. 6, pp. 727-730.
Mukaiyama et al., Bull. Chem. Soc. of Japan, vol. 44, No. 1, 1971.

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