Hydroxamino acid based collagenase inhibitors

Drug – bio-affecting and body treating compositions – Designated organic active ingredient containing – Radical -xh acid – or anhydride – acid halide or salt thereof...

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514616, 558230, 562621, 562623, A61K 3119, A61K 3116, C07C32704

Patent

active

053107632

ABSTRACT:
Compounds of general formula I: ##STR1## wherein: R.sup.1 represents a C.sub.1 -C.sub.6 alkyl, phenyl, thiophenyl, substituted phenyl, phenyl(C.sub.1 -C.sub.6)alkyl, heterocyclyl, (C.sub.1 -C.sub.6)alkylcarbonyl phenacyl or substituted phenacyl group; or, when n=O, R.sup.1 represents SR.sup.x, wherein R.sup.x represents a group: ##STR2## R.sup.2 represents a hydrogen atom or a C.sub.1 -C.sub.6 alkyl, C.sub.1 -C.sub.6 alkenyl, phenyl(C.sub.1 -C.sub.6)alkyl, cycloalkyl(C.sub.1 -C.sub.6)alkyl or cycloalkenyl(C.sub.1 -C.sub.6)alkyl group;

REFERENCES:
patent: 4599361 (1986-07-01), Dickens et al.
patent: 4743587 (1988-05-01), Dickens et al.
patent: 4918105 (1990-04-01), Cartwright et al.
patent: 4996358 (1991-02-01), Honda et al.

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