Hydroxamic derivatives and pharmaceutical compositions

Details Hydroxamic derivatives and pharmaceutical compositions Hydroxamic derivatives and pharmaceutical compositions

1993-05-24

1994-06-07

Ramsuer, Robert W.

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Heterocyclic carbon compounds containing a hetero ring...

5142352, 514253, 514323, 514326, 540602, 544 584, 544134, 544141, 544144, 544238, 544373, 546200, 546201, 546208, 546210, 546 19, 546188, 546209, 548465, 548477, 548181, A61K 3140, A61K 31535, C07D41306, C07D41706

Patent

active

053189647

ABSTRACT:
Hydroxamic acid derivatives of the formula ##STR1## and pharmaceutically acceptable salts thereof, which are collagenase inhibitors useful for the control or prevention of degenerative joint diseases, such as, rheumatoid arthritis and osteoarthritis or for the treatment of invasive tumors, atherosclerosis or multiple sclerosis, are described. Said compounds can be prepared either by hydroxamidating a corresponding carboxylic acid or deprotecting a corresponding benzyloxycarbamoyl compound.

REFERENCES:
patent: 4743587 (1988-05-01), Dickens et al.
Dayer et al. Proc. Natl. Acad. Sci. USA (1976), 73, 945.
Johnson-Wint. B. Anal. Biochem. (1980) 104, 175.
Handa, et al., Chemical Abstracts, vol. 108 (1988) No. 167,973e.
Broadhurst et al., Chemical Abstracts, vol. 118 (1993) No. 169,601n.

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