Hydroxamic and carboxylic acid derivatives having MMP and TNF in

Details Hydroxamic and carboxylic acid derivatives having MMP and TNF in Hydroxamic and carboxylic acid derivatives having MMP and TNF in

1997-08-07

2000-09-12

Richter, Johann

Organic compounds -- part of the class 532-570 series

Organic compounds

Heterocyclic carbon compounds containing a hetero ring...

548578, 5483001, 5483265, 5483355, 544239, 544235, C07D21196, C07D20748, C07D23502, C07D23704

Patent

active

061180017

ABSTRACT:
Disclosed are hydroxamic and carboxylic acid derivatives which are useful inhibitors of matrix metalloproteinase and/or TNF.alpha.-mediated diseases, including degenerative diseases and certain cancers.

REFERENCES:
patent: 4325964 (1982-04-01), Lafon
patent: 5698706 (1997-12-01), Baxter et al.
Eckstein, Z., and J. Tolak (1963) "On the Properties and Fungicidal Activity of Aryloxyalkanehydroxamic Acids. VI. Influnces of Iodines as Subtituent" vol. XI, No. 12, pp. 671-675.
Zayed, S.M.A.D., et al. (1966) "Preparation and Fungicidal Properties of Some Arythioalkanoyl- and (Arylsulphonyl)-aceto-hydroxamic Acids" Zeitschrift Fur Naturforschung, pp. 180-182.
Eckstein, Z., et al. (1958) "Hydroxamic Acids. VI. Chemical Properties and fungicidal actibity of some derivattives of Aryloxyacetohydroxamic Acids" Chemical Abstracts, vol. 52, No. 14, Column 11786, Abstract No. 11786h.

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