Hydroxamic acids of 7-oxabicyclo[2.2.1]heptane substituted ether

Details Hydroxamic acids of 7-oxabicyclo[2.2.1]heptane substituted ether Hydroxamic acids of 7-oxabicyclo[2.2.1]heptane substituted ether

1986-02-14

1987-03-31

Jiles, Henry R.

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Having -c-, wherein x is chalcogen, bonded directly to...

549463, A61K 3134, A61K 31557, C07D30700

Patent

active

046543660

ABSTRACT:
7-Oxabicycloheptane substituted ether or thio ether prostaglandin analogs are provided having the structural formula ##STR1## wherein A is O or ##STR2## and X is O or ##STR3## and including all stereoisomers thereof. The compounds are inhibitors of .DELTA..sup.5 -lipoxygenase and inhibitors of prostaglandin and leukotriene biosynthesis and as such are useful, for example, as antiallergy and antiinflammatory agents and also as antipsoriatic agents.

REFERENCES:
patent: 4143054 (1979-03-01), Sprague
patent: 4187236 (1980-02-01), Sprague
patent: 4220594 (1980-09-01), Sprague
patent: 4228180 (1980-10-01), Sprague
patent: 4254044 (1981-03-01), Sprague
patent: 4537981 (1985-08-01), Snitman et al.

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