Drug – bio-affecting and body treating compositions – Designated organic active ingredient containing – Nitrogen containing other than solely as a nitrogen in an...
Reexamination Certificate
2008-01-30
2010-10-05
Shiao, Rei-tsang (Department: 1628)
Drug, bio-affecting and body treating compositions
Designated organic active ingredient containing
Nitrogen containing other than solely as a nitrogen in an...
C564S161000
Reexamination Certificate
active
07807720
ABSTRACT:
Compounds having the formulawherein the symbols have the meaning described in the specification are hydroxamic acid derivatives of 3-phenyl-propionic acid and capable of inhibiting the lethal effects of infection by anthrax bacteria and are useful in the treatment of poisoning by anthrax.
REFERENCES:
patent: 4751296 (1988-06-01), Miller
patent: 6420427 (2002-07-01), Takahashi
patent: 2005/0148629 (2005-07-01), Xiong
patent: WO 97/24117 (1997-07-01), None
patent: WO 03/101382 (2003-12-01), None
patent: WO 2005/027856 (2005-03-01), None
Takahashi et al., 1999, CAS: 130:311803.
Gasparini et al., 1980, CAS: 92:66434.
Venkatesan et al., 1998, CAS: 129:230641.
U.S. Appl. No. 12/011,790, filed Jan. 30, 2008, Johnson.
U.S. Appl. No. 12/011,847, filed Jan. 30, 2008, Johnson.
Xiong et al. The discovery of a potent and selective lethal factor inhibitor for adjunct therapy of anthrax infection. Bioorg. Med. Chem. Lett. 2006; 16, 964-8. Compound 40.
Summers et al. Hydroxamic Acid Inhibitors of 5-Lipoxygenase: Quantitative Structure-Activity Relationships. J. Med. Chem. 1990, 33, 992-998. See Compounds 82, 94-96, p. 995.
Sparks et al.. Type 2 Intramolecular N-Acylnitroso Diels-Alder Reaction “ . . . ”. J. Org. Chem. 2004, 69, 3025-3035. Compound 4a to 4c. p. 3026.
Rajendra et al. Intramolecular Electrophilic Additins to Olefins in Organic Syntheses. Stereoselective Synthesis “ . . . ”. J. Org. Chem. 1987, 52, 4471-4477. See Compound 4b.
Couturier, M.; et al. 5,5-Dimethyl-1,4,2-dioxazoles as Versitle Aprotic Hydroxamic Acid Protecting Groups. J. Org. Chem. 2002, 67, 4833-4838. See Compound 1e and 1f, p. 4835.
Xianfeng, et al., Design and Evaluation of Hydroxamate Derivatives as Metal-Mediated Inhibitors of a Protein . . . , J. Med. Chem., 2006, 49, 7532-7539. See p. 7534.
Caplow, et al., Discrete Effects of the Acylamino Proton in a Chymotrypsin Substrate . . . , Journal of the American Chemical Society, 94:18, Sep. 6, 1972, pp. 6508-6512.
Jiao Guan-Sheng
Johnson Alan T.
PanThera Biopharma, LLC
Shiao Rei-tsang
Szekeres Gabor L.
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