Hydroxamic acid derivatives as inhibitors of HDAC enzymatic...

Details Hydroxamic acid derivatives as inhibitors of HDAC enzymatic... Hydroxamic acid derivatives as inhibitors of HDAC enzymatic...

2011-07-05

2011-07-05

Chu, Yong (Department: 1626)

Organic compounds -- part of the class 532-570 series

Organic compounds

Heterocyclic carbon compounds containing a hetero ring...

C514S443000, C514S542000, C560S039000

Reexamination Certificate

active

07973181

ABSTRACT:
Compounds of formula (I) are inhibitors of histone deacetylase activity, and are useful in the treatment of, for example, cancers:wherein Y1is a bond, —(C═O)—, —S(O2)—, —C(═O)O—, —OC(═O)—, —(C═O)NR3—, —NR3(C═O)—, —S(O2)NR3—, —NR3S(O2)—, or —NR3(C═O)NR5—, wherein R3and R5are independently hydrogen or optionally substituted (C1-C6)alkyl, L1is a divalent radical of formula -(Alk1)m(Q)n(Alk2)pwherein m, n, p, Alk1, Alk2and Q are as defined in the claims; z is 0 or 1; A represents an optionally substituted mono-, bi— or tri-cyclic carbocyclic or heterocyclic ring system; -[Linker]- represents a divalent linker radical; R is a radical of formula (X) or (Y):wherein R1is a carboxylic acid group (—COOH), or an ester group which is hydrolysable by one or more intracellular carboxylesterase enzymes to a carboxylic acid group; R4is hydrogen; or optionally substituted C1-C6alkyl, C3-C7cycloalkyl, aryl, aryl(C1-C6alkyl)-, heteroaryl, heteroaryl(C1-C6alkyl)-, —(C═O)R3, —(C═O)OR3, or —(C═O)NR3wherein R3is hydrogen or optionally substituted (C1-C6)alkyl, C3-C7cycloalkyl, aryl, aryl(C1-C6alkyl)-, heteroaryl, or heteroaryl(C1-C6alkyl)-; R41is hydrogen or optionally substituted C1-C6alkyl; and B is a monocyclic heterocyclic ring of 5 or 6 ring atoms wherein R1is linked to a ring carbon adjacent the ring nitrogen shown, and ring B is optionally fused to a second carbocyclic or heterocyclic ring of 5 or 6 ring atoms in which case the bond shown intersected by a wavy line may be from a ring atom in said second ring.

REFERENCES:
patent: 2004/0092558 (2004-05-01), Klimko et al.
patent: 2009/0291978 (2009-11-01), Davidson et al.
patent: 2010/0010010 (2010-01-01), Davidson et al.
patent: WO 01/18171 (2001-03-01), None
patent: WO 02/090534 (2002-11-01), None
patent: WO 03/070188 (2003-08-01), None
Vippagunta et al., Advanced Drug Delivery Reviews, vol. 48, (2001), pp. 3-26.

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