Hydroxamic acid derivatives and medicaments for treatment of uro

Details Hydroxamic acid derivatives and medicaments for treatment of uro Hydroxamic acid derivatives and medicaments for treatment of uro

1978-01-26

1979-06-05

Raymond, Richard

Drug, bio-affecting and body treating compositions

Antigen, epitope, or other immunospecific immunoeffector

Parasitic organism or component thereof or substance...

2603322C, 2603405R, 2603473, 2605005H, 424275, 424282, 424285, 424315, 546316, 546323, A61K 31455, C07D21356

Patent

active

041573960

ABSTRACT:
A novel compound having the general formula: ##STR1## wherein R.sub.1 is a residual group selected from the group consisting of substituted phenyl, carbonoylaminophenyl and heterocyclic groups, and R.sub.2 is hydrogen or methyl group, and its salts of a pharmacologically acceptable base and a novel medicament containing the compound or its salt mentioned above as a principal component; and the compound and the salt thereof having superior effect for the treatment of urolithiasis and the pyelonephrosis by exhibiting a strong urease inhibitory action, a high transfer rate into the urine and a low toxicity.

REFERENCES:
patent: 3728380 (1973-04-01), Johnson et al.
patent: 3993772 (1976-11-01), Pommer et al.
Hoffmann et al., Chemical Abstract, vol. 60 (1964), 14603g.

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